Clinical
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Capsaicin for Painful Diabetic Peripheral Neuropathy
An 8% capsaicin patch relieves pain and improves sleep in patients with painful diabetic peripheral neuropathy.
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Helping Women at Risk for Breast Cancer to Exercise More and Lose Weight
A web- and phone-based intervention led to significant weight loss and a modest increase in moderate-to-vigorous activity in women at risk of breast cancer.
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High-intensity Interval Training in Older and Younger Adults
High-intensity interval training performed over 12 weeks reversed age-related differences of mitochondrial proteins in adults 65 to 80 years of age, as well as increased insulin sensitivity and VO2 peak, and decreased fat free mass in adults 18 to 30 years of age and 65 to 80 years of age.
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Active Children: Do Higher Levels of Activity Help Prevent Depression?
This prospective study found moderate to vigorous physical activity in early childhood correlated with a decreased number of depressive symptoms in later years.
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Optimizing Electromyography in ALS
In the appropriate clinical setting, electromyography studies of multiple, distal muscle groups in three separate spinal regions showing acute and chronic denervation, are pathognomonic for the diagnosis of amyotrophic lateral sclerosis.
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EEG-based Metrics After Severe Brain Injury
In this cohort study of 104 patients with disorders of consciousness, the authors demonstrated a strong correlation between EEG-based metrics and clinical diagnosis using quantitative behavioral scales, brain metabolism as measured by PET, and clinical outcomes at one year.
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Risk Factors for Seizures in Critically Ill Patients Monitored by Continuous EEG
Investigators prospectively analyzed 72-hour continuous electroencephalograms to identify clinical and electroencephalogram risk factors for having seizures and developed a model for “time-dependent” seizure risk. Electrographic seizures occurred in 23% of all patients. The only significant clinical predictors of seizures were presence of coma and prior clinical seizure history.
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P-syn in Nerve Fibers on Skin Biopsy May Help Diagnose Dementia with Lewy Bodies
This study compared 18 subjects diagnosed with dementia with Lewy bodies (DLB), 23 with nonsynucleinopathy dementia, and 25 healthy controls and demonstrated that phosphorylated alpha-synuclein was found only in the skin nerve fibers of DLB subjects, helping distinguish this type of dementia from other types.
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Infectious Disease Alert Updates
Immediate Improvement in Childhood Vaccination; A Better Mosquito Trap; Can FMT Restore Gut Flora and Eliminate Resistant Pathogens?
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Is Sleep a Clue to a Modifiable Risk Factor for Alzheimer’s Disease?
Evidence is accumulating that disruptions in sleep patterns, particularly slow-wave and REM sleep, alter amyloid-β production and clearance through the cerebrospinal fluid pathways and may play a role in the development of Alzheimer’s disease.