Clinical
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Just Which Patients Are at Risk of Developing Uterine Fibroids?
Uterine fibroids occur commonly and are the most frequent reason for hysterectomy in the United States. Recognizing the risk factors for developing fibroids can help clinicians identify affected individuals and may lead to new approaches to treatment.
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Clinical Briefs
In this section: A better definition for celiac disease; shedding light on a vaccine; and treating asthma.
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Meropenem and Vaborbactam Injection (Vabomere)
The FDA has approved a new combination antibacterial for the treatment of complicated urinary tract infections.
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Is a Dabigatran Reversal Agent Effective?
A pragmatic clinical study of idarucizumab for counteracting the effects of the oral anticoagulant dabigatran showed rapid and complete reversal of its effects in patients with major bleeding or urgent surgery, without any adverse safety concerns.
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Mother Was Right: You Are What You Eat
In a study of simplified enterotypes as prognostic markers for successful body fat loss on two different diets, participants with a greater ratio of Prevotella to Bacteroides appeared more susceptible to lose body fat on diets high in fiber and whole grains.
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Diet High in Carbohydrates, Not Fats, Drives Mortality
A prospective epidemiological cohort study of people 35-70 years of age in 18 countries showed that a higher intake of carbohydrates increased total mortality, while the intake of fats of all kinds did not. A higher intake of saturated fat reduced stroke mortality.
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A Link Between Demodex Mites and Rosacea
The role of Demodex in rosacea appears to be well demonstrated. Since eradication of Demodex is insufficient to resolve rosacea, other pathophysiologic pathways also must be involved.
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More Good News for GLP-1 RA in Type 2 Diabetes
Since 2008, the FDA has required all new diabetes medications to provide evidence of cardiovascular (CV) safety. The good news is that several classes of agents have demonstrated not only CV safety, but even efficacy in reducing CV events and (in some cases) all-cause mortality.
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Menopausal Hormone Replacement
For women who use or have used hormone replacement for menopausal symptoms, new data should be reassuring that their symptom relief does not come at a cost of increased total or cancer-related mortality.
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Is It Safe to Use PPIs Long Term?
Proton pump inhibitors (PPIs) are among the most widely used medications in the United States, thanks to a generally favorable combination of efficacy, tolerability, and safety. Because such a large portion of the adult population uses PPIs, even if a small fraction experiences an adverse effect, it becomes a potentially important issue.