Clinical
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Spiritual Healing: A Randomized Clinical Trial
A randomized, controlled trial evaluated the effectiveness of Brazilian energy therapy — Spiritist “passé” — in multiple conditions associated with recovery in cardiovascular inpatients.
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Vitamin D and Colorectal Cancer: The Plot Thickens
In a follow-up study, researchers investigated whether single nucleotide polymorphism (SNP) genotypes in the vitamin D and calcium pathways are associated with the authors’ previous findings that daily intake of 1,000 IU vitamin D3 and/or 1,200 mg calcium did not reduce colorectal adenoma risk. The authors concluded that vitamin D3 supplementation benefits in the prevention of advanced colorectal adenomas may vary depending on vitamin D receptor genotype status.
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Physician Burnout: A Multi-specialty Perspective
Although different specialties address the problem of physician burnout, studies suggest the most effect is gained from organizational interventions.
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Infectious Disease Alert Updates
Travelers Unaware of the Need for Pre-travel Vaccinations; Fecal Microbiota Testing; Newer Guidelines for Influenza Testing This Season
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Chikungunya Locally Acquired in Italy and France
An outbreak of autochthonously acquired chikungunya infection has affected 298 individuals as of early October 2017, while a small outbreak also has occurred in southeastern France.
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Caring for Providers: Mindfulness for Healthcare Practitioners
Preliminary studies show some promise for use of mindfulness interventions in healthcare practitioners, but the time required for training medical providers in these techniques is identified as a limitation to implementation.
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How Many Personnel Are Required for Antimicrobial Stewardship? More Than You Have at Your Hospital
A work group in the Veterans Administration determined that the necessary staffing of antimicrobial stewardship programs dealing with inpatients (including long-term care) is 1.0 clinical pharmacy specialist with infectious disease knowledge and 0.25 physician (preferably trained in infectious disease) per 100 occupied beds. Needs for outpatient stewardship, which is now mandated, were not included in the assessment.
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Treatment of Pulmonary Mycobacterium avium Infection: Failure Is Common
Current treatment regimens for pulmonary Mycobacterium avium infection leave a great deal to be desired.
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Immunohistochemistry and Diagnosis of Viral Diseases
Researchers reviewed five years of cases at an academic medical center’s pathology department for the use of immunohistochemistry to detect CMV, HSV-1, HSV-2, varicella zoster virus, adenovirus, or polyomavirus. Of 957 cases, 134 were positive. Viral cytopathic effect (CPE) was present on hematoxylin and eosin staining in 75% of the IHC+ cases. No changes in clinical care occurred in any of the IHC+ cases in which viral CPE was absent.
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Mice, Mutations, and Microcephaly: The Evolving Pathogenesis of Congenital Zika Syndrome
Approximately five years ago, a single gene mutation altered Zika virus, making it able to target neuronal progenitor cells and cause what we now know as congenital Zika syndrome with microcephaly and ocular abnormalities.