Clinical
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Monitoring Bleeding Risks Associated With Non-vitamin K Oral Anticoagulants
In a recent trial, among patients taking non-vitamin K oral anticoagulants for atrial fibrillation, concurrent use of amiodarone, fluconazole, rifampin, and phenytoin was associated with increased risk of major bleeding.
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Lowering Dementia Risk in Atrial Fibrillation Patients
Oral anticoagulants may reduce the risk of dementia in patients with atrial fibrillation, according to a new study from Sweden.
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Possible Link Between Acetaminophen Use During Pregnancy and Later ADHD Development
A recent study showed that long-term maternal use of acetaminophen during pregnancy was associated substantially with ADHD, even after adjusting for indications of use, familial risk of ADHD, and other potential confounders. However, given that paternal use of acetaminophen also was associated with ADHD, the causal role of acetaminophen can be questioned.
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Considering Systemic Treatment for Atopic Dermatitis
A recent panel of eczema experts convened to provide advice about when clinicians should consider systemic treatment.
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Cardiorespiratory Fitness and Mortality
In both men and women in the United States, levels of cardiorespiratory fitness are inversely related to mortality. An encouraging epidemiologic study of women found that even brisk walking for about 30 minutes daily was associated with near maximal cardiovascular health benefits.
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Searching for Answers on Knee Osteoarthritis
Data consistently show that for knee osteoarthritis, weight loss is associated with symptomatic and functional improvement. The mechanism of this is incompletely understood, since weight loss has not been shown to affect the progressive degradation of cartilage typical of osteoarthritis.
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New Pharmacologic Direction for Parkinson’s Disease
Most clinicians are used to thinking about dopamine modulation when considering treatments for Parkinson’s disease. Unfortunately, none of the current treatments can be designated as disease-modifying, even though such treatment provides transient symptomatic relief.
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Morphine in Dyspneic Acute Heart Failure
Based on recent data, clinicians should avoid morphine use in acute heart failure patients.
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CV Benefits of GLP-1RA Treatment in Type 2 Diabetes
Among the sodium-glucose cotransporter 2 inhibitor and glucagon-like peptide-1 receptor agonist classes of pharmacotherapy, there appears to be much more similarity than not. Should clinicians consider these salubrious cardiovascular effects a class effect? That is, should all members of the class be anticipated to experience similarly favorable cardiovascular outcomes?
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Are Right-sided Leads Needed?
The ECG in the figure was obtained from a man in his 50s who presented with new severe chest pain. How would you interpret this tracing? What area(s) of the heart are involved? What is the likely culprit artery?