Clinical
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Does Postpartum Use of Hormonal Contraception Increase Risk of Depression?
An analysis of a large insurance database showed no consistent effect between postpartum initiation of hormonal contraception and the subsequent diagnosis of depression.
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Should Endocervical Curettage Be Performed Routinely During Colposcopy?
In this study, routine endocervical curettage (ECC) among women age 30 and older detected CIN 2 or worse in 14.4% of cases with higher likelihood of detection among women with high-grade squamous intraepithelial lesion, ASC-H, positive HPV 16 infection, or high grade colposcopic impression. The additional yield of ECC over lesion-directed ectocervical biopsies decreased with each additional biopsy.
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Dating Pregnancy: What Is the Most Accurate Method?
The NICHD Fetal Growth Studies – Singletons investigation recently yielded a new formula for determining gestational age based on standard biometric information. When compared to an often-used formula, it appeared to be more accurate after 21 weeks of gestation.
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What Do the Urinary Microbiota and Incontinence Have to Do With Each Other?
Increased diversity of the microbiota in women is associated with urgency urinary incontinence symptoms but not with stress urinary incontinence symptoms.
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Clinical Briefs
In this section: considering cardiorespiratory fitness and mortality; searching for answers on knee osteoarthritis; and comprehensive treatment for atopic dermatitis.
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Abemaciclib Tablets (Verzenio)
Abemaciclib is indicated in combination with fulvestrant for the treatment of women with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy.
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Cardiac Stenting No Better Than Aggressive Medical Management for Stable Angina and Single Vessel Disease
Investigators conducted the first blinded, randomized trial comparing percutaneous coronary intervention with medical management.
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Migraine With Aura, Stroke Risk, and Biomarkers
The authors of a longitudinal cohort study of twins found no increased stroke risk related to migraine overall, but there was a modestly increased risk for stroke related to migraine with aura. Familial factors and vascular biomarkers associated with migraine with aura may explain its correlation with vascular disease.
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Procalcitonin to Guide Antibiotic Therapy for Acute Respiratory Infections
The authors of this meta-analysis reviewed patient-level data on 6,708 patients from 26 randomized studies that examined procalcitonin-directed antibiotic therapy for acute respiratory tract infections. They found a 1% reduction in mortality and a 2.4-day reduction in antibiotic exposure for the procalcitonin-directed therapy groups. How procalcitonin can be incorporated into routine clinical practice, in what settings, and whether it is cost-effective are still unclear.
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Reducing Falls Among Older Adults
Exercise, correction of impaired vision, supplemental calcium/vitamin D, and environmental interventions reduce falls. Interventions that are multimodal appear to produce additive benefits.