Clinical
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Assessing Device-assisted CPR Safety
A randomized, prospective, noninferiority study of the safety of two automated CPR devices (LUCAS and AutoPulse) against the standard manual chest compressions in cardiac arrest victims showed that in cases of severe or life-threatening complications, the LUCAS device was noninferior to standard CPR, but more organ damage with the AutoPulse cannot be excluded.
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Research Provides More Support for Antiplatelet Therapy De-escalation
The authors of a single-center study randomized post-acute coronary syndrome patients either to remain on higher-potency antiplatelet agents or to change to clopidogrel after one month. The results showed a benefit to de-escalation in terms of both bleeding and ischemic events, regardless of initial platelet reactivity.
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Clinical Briefs
In this section: Finding the prescription for the best diet, treating severe acute pain in the ED, and reducing falls among older patients.
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Ertugliflozin Tablets (Steglatro)
Ertugliflozin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
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The Incidence of Dementia May Be Declining
In community-dwelling people from Bronx County, New York, there was a sharp decrease in dementia incidence in those born after mid-1929, which could not be readily explained by changes in the prevalence of cardiovascular diseases, higher education, or increased racial/ethnic diversity.
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CT Calcium Score vs. Stress Testing
A subgroup analysis of the PROMISE trial showed that CT coronary calcium scores in symptomatic patients at low to intermediate risk for coronary artery disease are more sensitive but less specific for major adverse cardiac events over a two-year follow-up period than stress testing. Consequently, both approaches exhibited similar but modest discriminatory ability.
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Hold the Hormones — At Least for Chronic Condition Prevention
The U.S. Preventive Services Task Force reissued a statement on hormone replacement therapy for the prevention of chronic conditions that reiterates its D recommendation from 2012. It recommends physicians do not prescribe hormone replacement therapy (HRT) to prevent medical conditions, but leave the question of using HRT for treatment of menopausal symptoms unanswered.
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The Debate Continues on Salpingectomy
The role of routine salpingectomy during vaginal hysterectomy is controversial.
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Intrauterine Device String Checks: Are They Necessary?
Two-thirds of women complied with the recommendation for a six-week follow-up visit after intrauterine device (IUD) insertion. Among these women, 19.8% had their IUD removed in the first year compared to 12.6% among women who did not attend the follow-up visit. The majority of removals occurred outside the six-week follow-up period.
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Does Hysterosalpingography With Oil-based Contrast Increase Fertility?
A multicenter, randomized trial in the Netherlands documented higher rates of ongoing pregnancy and live births among infertile women who underwent hysterosalpingography with oil-based contrast compared to those who underwent the procedure with water-based contrast.