Clinical
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Ozenoxacin Cream 1% (Xepi)
Ozenoxacin is indicated for the topical treatment of impetigo due to S. aureus and S. pyogenes in adult patients and pediatric patients ≥ 2 months of age.
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Updated Recommendations for Prevention of Hepatitis B Virus Infection
Fresh recommendations for prevention of hepatitis B virus infection focus on testing and management of newborns.
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Functional Imaging Studies in Parkinson’s Disease
A meta-analysis of 142 studies demonstrated that functional imaging studies in Parkinson’s disease using tracers for aromatic acid decarboxylase showed smaller defects compared to those using tracers targeting dopamine transport and VMAT2. Symptom severity correlated linearly with dopamine neuron loss as determined by these imaging studies.
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A Closer Look at the Effects of NSAIDs on Blood Pressure
An ambulatory blood pressure monitoring substudy of the PRECISION trial showed that ibuprofen use significantly increased mean 24-hour systolic blood pressure compared to celecoxib. Further, naproxen produced intermediate results despite equivalent pain relief in patients with arthritis.
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Kratom Alert: FDA Concerns
Kratom, a plant that is banned in some countries, is available in the United States and has some safety concerns, mostly related to its opioid-like effects.
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Prevalence of Cognitive Impairment in Older Women With Pelvic Floor Disorders
Mild cognitive impairment and early dementia are prevalent in women seeking care for pelvic floor disorders.
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Oxytocin Discontinuation
A recent meta-analysis of randomized, clinical trials has shown that discontinuing oxytocin infusion once active labor has been attained in inductions and augmentations of labor will result in a reduction of cesarean delivery and tachysystole, but an increase in the length of labor.
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Which Antibiotics Are Safe in the First Trimester of Pregnancy?
A total of 7.2% of pregnant women were diagnosed with a urinary tract infection, and of these, 69% filled an antibiotic prescription. The most common antibiotics prescribed in the first trimester were nitrofurantoin, ciprofloxacin, cephalexin, and trimethoprim-sulfamethoxazole.
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Fetal Fibronectin: Its Role in Threatened Preterm Labor
A recent letter to the editor disputes the conclusion of an earlier study that fetal fibronectin is of little value in threatened preterm labor, despite other studies suggesting that when used in conjunction with cervical length measurements, it can diminish unnecessary hospitalizations appreciably.
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FDA Actions
In this section: The agency tackles loperamide abuse, approves new breast cancer treatment, updates guidance on opioid cough and cold medications, promotes new opportunities to battle the opioid epidemic, and issues new indication for an irritable bowel drug.