Clinical
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Migalastat (Galafold) Capsules
Migalastat is indicated for the treatment of adults with confirmed diagnosis of Fabry disease and an amenable galactosidase alpha gene variant based on in vitro assay data.
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Poor Sleep Can Lead to Accelerated Atherosclerosis
New data provide further support for the importance of sleep in the optimization of medical outcomes.
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Coffee Consumption and Mortality
After rigorous evaluation using multiple statistics, an inverse relationship between coffee intake and all-cause mortality was demonstrated consistently across the racial/ethnic groups examined.
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Can Hormone Therapy Prevent the Development of a ‘Dowager’s Hump’?
Postmenopausal hormone therapy may reduce the risk of developing age-related hyperkyphosis, commonly known as a “Dowager’s hump.” Such therapy may provide long-term benefits.
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Carbohydrates, Insulin, and Obesity
Carbohydrate intake stimulates insulin secretion, which is the primary driver of weight gain. Besides driving glucose into cells, insulin causes fat storage, increases hunger, and lowers energy expenditure. High insulin blood levels lead to obesity with some genetic variation.
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Expedited Partner Therapy: We Can Do More
This article reviews the current status of expedited partner therapy (EPT), which involves treating the heterosexual partners of patients diagnosed with chlamydia or gonorrhea by providing the medication or a prescription for the patient to give to the partner without a healthcare provider first examining the partner.
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Nocturia: Does Salt Intake Play a Role?
Researchers suggest that excessive salt intake can contribute to urinary frequency and nocturia.
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Premature Rupture of Membranes Revisited
An individual participant data meta-analysis from Australia suggests that expectant management of patients with premature rupture of membranes between 34 and 36 weeks, compared with immediate intervention, results in comparable levels of composite neonatal adverse outcomes but in mixed maternal adverse outcomes that balance out in the final analysis.
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Childhood Obesity: A Risk Factor for Infertility?
Results from a 25-year prospective study demonstrate a moderate association between childhood obesity before age 12 years and female infertility in adulthood.
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Why Are Cesarean Delivery Rates Higher With IVF Pregnancies?
SYNOPSIS: The major factors leading to increased odds of cesarean delivery in all infertile women, but particularly in those who conceive following in vitro fertilization, are advanced maternal age and previous uterine surgery.