Clinical
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Caplacizumab-yhdp for Injection (Cablivi)
Caplacizumab-yhdp is indicated for the treatment of acquired thrombotic thrombocytopenic purpura in combination with plasma exchange and immunosuppressive therapy.
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Homeless Population Requires Hepatitis A Vaccination
A multistate outbreak of hepatitis A virus (HAV) infection in the homeless and/or drug-using population has prompted the United States Advisory Committee on Immunization Practices to add “homelessness” as an indication for HAV vaccination. This is in addition to existing indications for HAV vaccination of men who have sex with men and illicit drug users (with the exception of marijuana use).
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Combination Drug Therapy for Hypertension
A large regional database study from Italy revealed that initial combination therapy for newly diagnosed hypertension results in fewer major adverse cardiovascular events at one year compared to monotherapy.
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Clinical Outcomes After Oral Anticoagulant-Associated Intracerebral Hematoma
In this meta-analysis of multiple observational studies, clinical outcomes after oral anticoagulant-associated intracerebral hematoma were similar for those associated with vitamin K antagonists or the new class of direct oral anticoagulants.
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Apolipoprotein E and CSF Levels in Men and Women With Alzheimer’s Disease
Apolipoprotein E epsilon 4 (APOE4) genotype, the stronger genetic risk factor for late-onset Alzheimer’s disease, negatively affects cerebrospinal levels of tau protein in a sex-dependent manner, whereby the effect of APOE4 is stronger in women than men.
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State Policymakers Work Toward and Against a Post-Roe Country
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Trial Underway for Vaginal Ring Device Designed for HIV Prevention
Researchers are evaluating a vaginal ring designed to protect women against both HIV and herpes simplex virus type 2 in a Phase I study. The trial is being conducted by researchers from the National Institutes of Health-funded Microbicide Trials Network at three U.S. sites in Alabama, California, and Pennsylvania.
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FDA Approves New Test for Mycoplasma genitalium
The Food and Drug Administration has approved the first test to help with the diagnosis of Mycoplasma genitalium, a sexually transmitted infection.
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Researchers Investigate Microneedle Skin Patch Technology for Contraception Delivery
Researchers are studying microneedle skin patch technology for providing a long-acting contraceptive method that can be self-administered.
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Providers Can Improve Teen HPV Vaccination Rates
According to a new study, only about 16% of U.S. adolescents have received the complete vaccination against human papillomavirus (HPV) by the time they turn 13 years of age, despite national recommendations for vaccination at ages 11-12.