Clinical
RSSArticles
-
Alcohol Use: No Safe Level
A systematic analysis of data from the Global Burden of Disease Study 2016 on alcohol-linked disorders and patterns of alcohol use over 25 years worldwide found there is no safe level of alcohol consumption.
-
Effect of Diet on Hippocampal Volume in a Population at Risk for Alzheimer’s Disease
Magnetic resonance imaging of the brain in community-dwelling people (average age of 60 years) found that a long-term, high-quality diet was associated with larger hippocampal volumes after an average interval of 11 years.
-
Trends in Supplemental Vitamin D Intake
The authors investigated the trends in daily supplemental vitamin D intake of ≥ 1,000 IU and ≥ 4,000 IU and found increasing use of vitamin D supplementation.
-
Clinical Outcomes After Oral Anticoagulant-Associated Intracerebral Hematoma
In this meta-analysis of multiple observational studies, clinical outcomes after oral anticoagulant-associated intracerebral hematoma were similar for those associated with vitamin K antagonists or the new class of direct oral anticoagulants.
-
Correlation of Electromyography With Pathology in Myopathy
A detailed analysis of electromyography features showed a high correlation with muscle pathology. However, pathologic changes on muscle biopsy may be present even with a totally normal electromyogram.
-
Apolipoprotein E and CSF Levels in Men and Women With Alzheimer’s Disease
Apolipoprotein E epsilon 4 (APOE4) genotype, the stronger genetic risk factor for late-onset Alzheimer’s disease, negatively affects cerebrospinal levels of tau protein in a sex-dependent manner, whereby the effect of APOE4 is stronger in women than men.
-
Utility of Ictal Magnetoencephalography for Identifying Seizure Onset Zone
In a review of 377 magnetoencephalography (MEG) studies in epilepsy patients undergoing presurgical workup, 44 patients were found to have one or more seizures during routine recordings, lasting up to a mean of 51.2 minutes. Ictal MEG provided unique localizing data in about one-third of patients. For patients with frequent seizures or reliably induced seizures, MEG may be a useful supplemental tool for medically refractory epilepsy patients undergoing presurgical evaluation.
-
Effect of Sleep on Levodopa-Induced Dyskinesia in Parkinson’s Disease
Parkinson’s disease is associated with sleep disorders commonly. Disrupted sleep patterns appear to make dyskinesias worse in patients treated with levodopa therapy.
-
Insulin Therapy for Type 2 Diabetes: Social, Psychological, and Clinical Factors
The choices for insulin therapy are ever increasing with the development of new products that provide greater flexibility, greater range of effectiveness, lower risk of hypoglycemia, and lower pharmacokinetic and pharmacodynamic variability. These allow for individualization of treatment to match a patient’s daily life but typically at greater cost. This article will review the psychological, social, and clinical factors pertaining to the various insulin products, as well as strategies to initiate and intensify insulin therapy, to help clinicians supplement and enhance their clinical practices in diabetes management.
-
Noninvasive Mapping and Ablation of Ventricular Tachycardia: Evidence Builds for Novel Approach
In 19 patients with treatment-refractory episodes of ventricular tachycardia or frequent premature ventricular contractions, stereotactic body radiation therapy was highly effective at reducing arrhythmia burden without acute toxicity.