Clinical
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Team-Based Approach Associated With Better Outcomes in Cardiogenic Shock
Implementation of a standardized, team-based approach to cardiogenic shock resulted in improved 30-day survival compared to historical controls.
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Brexanolone Injection (Zulresso)
Brexanolone is indicated for the treatment of postpartum depression.
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Update on Treatments for Vulvovaginal Atrophy
As with many clinical conditions, the spectrum of genitourinary syndrome of menopause requires the clinician to consider the effect on the patient’s quality of life. Although situational lubricants and regular moisturizers effectively pacify many symptoms, local estrogen is a safe, effective, and affordable way to treat the vulvovaginal changes of menopause.
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Imagine: Multidrug-Resistant Acute Gonococcal Infection
What would happen if clinicians lost ceftriaxone as an effective therapy for gonococcal infection?
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Probiotics Do Not Prevent C. difficile Infection in Hospitalized Patients
A retrospective cohort study from a single California hospital revealed the administration of probiotics to patients receiving antibiotics did not reduce the incidence of healthcare facility-onset Clostridioides difficile infection.
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Does Physical Activity Lower the Risk of Parkinson’s Disease?
A systematic review and meta-analysis incorporating more than 500,000 subjects revealed that moderate to vigorous physical activity is associated with a significant reduction in development of Parkinson’s disease; this relationship is most pronounced in men.
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Thank You, John Hobbins; Welcome Camille Hoffman
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Should All Pregnant Women Be Screened for Hepatitis C?
In this cost-effectiveness analysis using Markov modeling, investigators found that universal antenatal screening for hepatitis C was cost-effective, with a mean incremental cost-effectiveness ratio of approximately $3,000 per quality-adjusted life years gained compared to risk-based screening.
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Staged Preeclampsia Screening in Early Pregnancy
The use of 150 mg of daily aspirin from 11 to 14 weeks through 36 weeks of gestation reduces the rate of early preeclampsia (PE) in approximately 90% of at-risk pregnancies. In addition, aspirin also provides the benefit of reducing the risk of PE < 37 weeks by about 60% and the length of NICU stay by about 70%, primarily by reducing the number of neonates delivered before 32 weeks. What constitutes a high-risk patient and what quantifies patient-specific risks before PE develops remain to be answered.
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The Changing Face of Labor Management
Throught the years, clinicians' understanding of the conduct of labor has undergone periodic re-evaluation. In the 1950s, cesarean delivery was a major operation. Today, the procedures are shorter, accompanied by less surgical fanfare, and associated with fewer days in the hospital. Nevertheless, as the only other option to vaginal delivery, the operation, performed in 35% of cases for failure to progress, still should be considered “major” considering its potential for maternal complications.