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Should Antibiotic Prophylaxis Be Used for Surgical Treatment of Early Pregnancy Loss?
In this randomized, controlled trial of more than 3,000 women in developing countries with incomplete or missed abortion at less than 22 weeks’ gestation, antibiotic prophylaxis prior to uterine evacuation reduced infection rates when a strict definition for pelvic infection was used, but not when a more expanded definition was used.
Behavioral Interventions for Menopausal-Related Insomnia Improve Depression
In a randomized, controlled trial comparing the behavioral interventions cognitive behavioral therapy for insomnia (CBTI) and sleep reduction therapy (SRT) to a control intervention of sleep hygiene education, investigators found CBTI and SRT therapy improved insomnia and depressive symptoms in postmenopausal women with menopausal-related insomnia.
Changes in Cervical Cancer Staging
This paper is an epidemiologic validation of recent changes in cervical cancer staging.
Annual User Survey
Why Is the QRS Wide?
The ECG in the figure belongs to an older woman who called EMS because of new-onset chest pain. How might one interpret the tracing? Why is the QRS complex wide?
Erdafitinib Tablets (Balversa)
Erdafitinib is the first FDA-approved targeted therapy for metastatic bladder cancer.
The Promise and Perils of the Apple Heart Study
A large study with virtual enrollment of Apple Watch users helped illustrate the positive predictive value of wearable, pulse-based atrial fibrillation detection technology, as well as the ability to enroll and follow huge numbers of research subjects in a short period.
How Safe Are New Medications for Type 2 Diabetes?
In recent years, new medications have been approved for the management of type 2 diabetes, generally after metformin is given. The FDA has reported 55 cases of Fournier’s gangrene in patients using SGLT2 inhibitors. These medications may not be worth the risk when lifestyle alternatives are available.
Late Sunsets, Sleep Deprivation, and Adverse Outcomes
All living organisms have 24-hour circadian rhythms. A growing body of evidence shows that chronic disruption of this important rhythm may result in poor health outcomes. These negative consequences of disrupted circadian rhythms might be prevented by modifying work and sleep schedules.
Drug Combination Considered for Treatment-Resistant Gonorrhea
Newly released research indicates that a certain combination of drugs, gentamicin and azithromycin, may work as well as ceftriaxone alone for cases of drug-resistant gonorrhea.