Clinical
RSSArticles
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Rifamycin Delayed-Release Tablets (Aemcolo)
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A Rabies Death in Virginia
A Virginia resident who had not received pre- or post-exposure prophylaxis died of rabies resulting from a dog bite during a prolonged trip to India. Many exposed healthcare workers subsequently received post-exposure prophylaxis.
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Rotavirus Vaccine and Hospitalization for Seizures
In an analysis of insurance claims for 1.8 million U.S. children with 2,950 recorded seizures, researchers found that the risk of hospitalization for seizures was 24% lower in rotavirus-vaccinated children.
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Duration of Intravenous Antibiotic Therapy for Late-Onset Neonatal Group B Streptococcal Bacteremia
Although standard treatment of late-onset neonatal group B Streptococcus bacteremia includes intravenous antibiotic therapy for 10 days, shorter courses seem safe and effective.
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A Nosocomial Outbreak at the NIH Clinical Center From Sphingomonas koreensis, a Rare Human Pathogen
A genomic and epidemiologic investigation of an outbreak at the National Institutes of Health Clinical Center determined that S. koreensis was an opportunistic human pathogen that persisted in a reservoir in the hospital plumbing.
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Treatment of Gram-Negative Bacteremia: How Long Is Long Enough?
Antibiotic administration for seven days is sufficient in stable patients with Gram-negative bacteremia.
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Are Frequent PVCs Causing Left Ventricular Dysfunction?
Premature ventricular contraction-induced cardiomyopathy was phenotypically different than a tachycardia-mediated cardiomyopathy in a swine model. Paced ventricular bigeminy led to left ventricular dyssynchrony, a decline in left ventricular ejection fraction associated with biventricular myocardial fibrosis, and a widening of the sinus QRS.
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In-Ambulance Troponin Measurements
A study of triaging suspected non-ST-elevation acute coronary syndrome patients by employing in-ambulance troponin measurements augmented the predictive value for 45-day major adverse cardiac events. This could help identify very high-risk patients who would benefit from urgent coronary angiography.
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The Natural History of Tricuspid Regurgitation
A retrospective analysis of patients with moderate or severe tricuspid valve regurgitation (TR) and who underwent an earlier echo with no or mild TR showed that progression of TR was independently associated with age, female sex, new device leads, and right ventricular or tricuspid annular dilation.
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TAVR Beneficial for Patients With Severely Reduced Ejection Fraction
In patients with low-flow, low-gradient aortic stenosis and severe left ventricular dysfunction, transcatheter aortic valve replacement was associated with significant improvement in left ventricular ejection fraction and similar mortality compared to patients with milder left ventricular dysfunction.