Clinical
RSSArticles
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In Memoriam: James Trussell, PhD
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Long-Acting Reversible Contraception: Progress Made, but Challenges Remain
In 2002, just 2.4% of U.S. women using birth control were using long-acting reversible contraceptive (LARC) methods, such as the intrauterine device or the contraceptive implant. By 2014, about 14% of women using birth control reported LARC use.
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Exercise and the Aging Immune System
The authors of this literature review detailed changes in immune system function that occur with age, as well as the immunological effects of acute and chronic exercise.
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The Effect of Vitamin D Supplementation on Fractures, Falls, and Bone Mineral Density
The authors of this systemic review, random-effect meta-analysis, and trial sequence analysis suggested that vitamin D supplementation does not have clinically significant effects on bone mineral density or the prevention of fractures or falls.
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Weight Loss Maintenance — Is Low-Carb the Key? An Investigation Into the Metabolic Effect of Diet
Researchers found that among adults seeking to maintain weight loss, consumption of a low-carbohydrate diet led to the highest total energy expenditure.
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Lettuce for Sleep? Maybe, but Not in Salad Form
The authors of this single-blind randomized study found that 1,000 mg of culinary lettuce seed nightly for two weeks can improve sleep in pregnant women with insomnia.
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Thinking Outside of the ‘Alpha-Synuclein Box’: A Critical Role of Tau in Lewy Body Disorders
Neocortical tau pathology was associated with worse antemortem cognition in this large study of Parkinson’s disease dementia and dementia with Lewy bodies. Regional brain variations correlated with specific cognitive domains.
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Predicting the Risk of Mild Cognitive Impairment Using Imaging Biomarkers
In this population-based study, researchers used imaging biomarkers of amyloid and neuronal injury to estimate an absolute risk of mild cognitive impairment in the elderly.
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Amyloid-ß Pathology Induced by Contaminated Cadaver-Derived Growth Hormone
Cadaveric pituitary-derived growth hormone that previously was known to transmit Creutzfeldt-Jakob disease (CJD) also contains ß-amyloid. Growth hormone vials from cases associated with amyloid plaques in CJD patients cause amyloid plaque formation and cerebral amyloid angiopathy when injected intracranially into mice.
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Rituximab for CIDP Associated With Systemic Immune Disorders
Rituximab has been used “off label” for the treatment of primary chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with variable reports of success. These authors reported a high rate of response in patients who developed CIDP in the setting of other systemic immune-mediated disorders.