Clinical
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Common Foot Problems
Foot problems are a common chief complaint. Patients may present to the ED when they do not have access to other sources of care or when an exacerbation becomes painful enough. Although these foot problems rarely are considered emergencies, it is useful for the emergency physician to be knowledgeable about these conditions to provide sound advice to patients and appropriate referral.
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Infectious Disease Alert Updates
Surgeons Really Are Different; Short-Course Atovaquone/Proguanil for Malaria Prophylaxis; The High Cost of Chronic Lyme Treatment
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Trimethoprim Sulfamethoxazole Plus Clindamycin for Treatment of Staphylococcus aureus Endocarditis
A before-and-after intervention study compared 170 patients treated with either oxacillin IV or vancomycin IV for six weeks (plus gentamicin IV given during the first five days) to 171 patients who were treated with TMP/SMZ IV plus clindamycin IV for the first week followed by TMP/SMZ PO (without clindamycin) to complete a six-week course. Mortality and hospital length of stay were significantly less in the TMP/SMZ-treated patients.
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Checkpoint Inhibitors: The First Effective Therapy for Progressive Multifocal Leukoencephalopathy?
Enhancing the immune response with checkpoint inhibitors may be beneficial in the management of progressive multifocal leukoencephalopathy, a viral disease previously recalcitrant to therapy.
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Significance of Pyuria in Children With Neurogenic Bladder
Pyuria is common in asymptomatic children with neurogenic bladders, especially after bladder surgery. The simple presence of pyuria does not necessarily indicate a need for antibiotic treatment.
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Babesiosis — Increase in Reported Cases in the United States
The number of cases reported to the CDC from 2011-2015 has increased and there is concern about expansion of the areas in which it is transmitted.
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Isavuconazole vs. Caspofungin for Candidemia
In a large, randomized, double-blind, multicenter clinical trial, researchers found that isavuconazole did not meet the primary endpoint of noninferiority compared to caspofungin for candidemia and invasive candidiasis.
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Trajectory of Physical Function Recovery May Help Inform Prognosis for Survivors of Acute Respiratory Failure
There are several distinct trajectories of recovery after acute respiratory failure. The group with the highest physical function consisted primarily of younger women who experienced less continuous sedation time and shorter ICU length of stay.