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Is It Safe to Stop Digoxin for Heart Failure?
In a large older patient heart failure with reduced ejection fraction hospitalizations database, the outcome of withdrawing digoxin vs. continuing digoxin was examined at 30 days and up to four years of follow-up. Withdrawing preadmission digoxin in hospital resulted in higher mortality at 30 days and more readmissions at six months, one year, and four years.
Complete Revascularization After STEMI: Do We Finally Know the Answer?
In this largest trial to date, patients who were randomized to complete revascularization by percutaneous coronary intervention (PCI) following successful intervention at the time of ST-elevation myocardial infarction (STEMI) had a lower risk of cardiovascular death, myocardial infarction, and ischemia-driven revascularization vs. patients who underwent culprit lesion-only PCI.
Molecular Analysis of Endometrial Cancer Corresponds With Outcomes in Young Women
SYNOPSIS: In this retrospective cohort study, researchers studied the prognosis and outcomes for young women with endometrial cancer and compared them according to tumor molecular classification.
Association Between Self-Reported Prenatal Cannabis Use and Maternal, Perinatal, and Neonatal Outcomes
Cannabis use during pregnancy has become commonplace in states and countries (Canada) where it has been legalized for medical and/or recreational use. The authors of this study attempted to determine whether associations exist between self-reported prenatal cannabis use and maternal and perinatal outcomes.
Does Vaginal Estradiol Reduce Pain With Sexual Activity?
A post-hoc analysis of data from a 12-week randomized study that compared vaginal estradiol to vaginal moisturizers found no increase in sexual frequency or decrease in pain associated with either treatment, compared to placebo.
Diagnostic Imaging Trends Among Pregnant Women
This retrospective cohort study estimated that the use of CT scans has increased 3.7-fold in the United States and 2-fold in Ontario, Canada, from 1996 to 2016. Overall, 5.3% of pregnant women in the United States and 3.6% in Ontario underwent imaging with ionizing radiation.
Are the Changes New, Recent, or Old?
Imagine examining the ECG in the figure below without any accompanying clinical information. How would one interpret this tracing? What might one suspect is going on?
Imipenem, Cilastatin, and Relebactam Injection (Recarbrio)
The FDA has approved a new antibacterial drug combination for complicated urinary tract infections and complicated intra-abdominal infections.
Hot Beverages and Esophageal Cancer
In a cohort of more than 50,000 people, there was a higher risk of esophageal squamous cell carcinoma in those who consumed higher quantities of mostly black tea at hotter temperatures.
Reducing Mortality in Stable Ischemic Heart Disease Patients
A multivariate analysis of a large registry of patients with stable ischemic heart disease revealed that beta-blocker use was associated with lower mortality only when prescribed in the first year after acute myocardial infarction.