Clinical
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Amyloid, Tau, Neurodegeneration Diagnostic Framework to Predict Memory Decline Before the Onset of Dementia
In a population-based longitudinal study of older individuals without dementia, the inclusion of imaging biomarkers for amyloid, tau, and neurodegeneration modestly improved the ability to predict memory decline compared to a model that only used clinical data and APOE genotype.
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Blood Pressure Targets in the Elderly
The authors of a large population study found that reducing blood pressure to < 140/90 mmHg is associated with increased mortality, and mortality was highest in those with previous cardiovascular events and age > 80 years.
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Vaping and Severe Acute Pneumonitis
Hundreds of cases of lung injury possibly related to vaping have been reported to the CDC. Evidence to date suggests the illness is a form of acute lipoid pneumonia likely related to inhalation of lipid materials.
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Recommendations for the Use of Testosterone Therapy in Women: A Global Consensus Statement
Exogenous testosterone is currently indicated only for women with documented hypoactive sexual desire disorder/dysfunction.
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Consensus Position Statement on the Use of Testosterone in Women
A task force of representatives from leading international societies issued guidance for appropriate prescribing of testosterone in women.
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Intrauterine Device Use and Ovarian Cancer Risk
In this systematic review, the odds ratio of ever-use of an intrauterine device and incident ovarian cancer was 0.68 (95% CI 0.62-0.75).
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Sedentary Behavior, Physical Activity, and Nighttime Urinary Symptoms
Sedentary behavior is associated with more severe symptoms of nocturia and nocturnal enuresis in women with urinary incontinence.
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What Might Account for the ST-T Changes?
The ECG in the figure was obtained from a 65-year-old woman who presented with an exacerbation of heart failure. A medical history revealed she was taking multiple medications. The patient was dyspneic and complained about intermittent chest pain.
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Pitolisant Tablets (Wakix)
Pitolisant should be prescribed to treat excessive daytime sleepiness in adult patients with narcolepsy.
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When Did You Last Take an Antibiotic?
Approximately half of U.S. residents with health insurance filled an antibiotic prescription over a two-year period.