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Isavuconazole vs. Caspofungin for Candidemia
In a large, randomized, double-blind, multicenter clinical trial, researchers found that isavuconazole did not meet the primary endpoint of noninferiority compared to caspofungin for candidemia and invasive candidiasis.
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Trajectory of Physical Function Recovery May Help Inform Prognosis for Survivors of Acute Respiratory Failure
There are several distinct trajectories of recovery after acute respiratory failure. The group with the highest physical function consisted primarily of younger women who experienced less continuous sedation time and shorter ICU length of stay.
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Impact of Early Low-Dose Norepinephrine in Adults Experiencing Sepsis With Hypotension
Adult patients experiencing sepsis with hypotension but who did not meet the definition of septic shock received a median of 800 mL of intravenous fluid prior to initiation of norepinephrine 0.05 mcg/kg/min as a non-titratable infusion. Patients in this early vasopressor group had much lower odds of failing to achieve their primary outcome of adequate mean arterial pressure and tissue perfusion when early norepinephrine was provided.
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Heparin-Induced Thrombocytopenia: What’s the Latest?
Heparin-induced thrombocytopenia is an iatrogenic, potentially life-threatening complication that occurs after exposure to heparin therapy in hospitalized patients. Early recognition and timely initiation of treatment are critical for improved prognosis.
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Treating Infective Endocarditis in Moderate-Risk Patients
There are patients with a moderate risk of infective endocarditis who may warrant consideration of antibiotic prophylaxis.
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Positive Outcomes With One Month of Dual Antiplatelet Therapy After PCI
One month of dual antiplatelet therapy (DAPT) followed by single antiplatelet therapy with clopidogrel was noninferior to 12 months of DAPT following percutaneous coronary intervention with drug-eluting stents.
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Reducing Mortality in Stable Ischemic Heart Disease Patients
A multivariate analysis of a large registry of patients with stable ischemic heart disease revealed that beta-blocker use was associated with lower mortality only when prescribed in the first year after acute myocardial infarction.
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Do Antianginal Agents Prevent Revascularization Procedures?
For patients with stable ischemic heart disease, adding either ranolazine or calcium channel blockers to nitrate or beta-blocker therapy reduced the incidence of subsequent revascularization and costs vs. beta-blocker or nitrate therapy alone or in combination.