Clinical
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Calcitonin Gene-Related Peptide Targeting Therapies for Migraine
Two randomized clinical trials showed that calcitonin gene-related peptide targeting therapies are effective and safe for primary headache disorders.
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Antisense Oligonucleotide Treatment of Huntington’s Disease: A Novel Potential Treatment
In this Phase I/IIa clinical trial, investigators administered antisense huntingtin oligonucleotides intrathecally to patients with early Huntington’s disease (HD), and demonstrated safety, tolerability, and dose-dependent reduction in CSF mutant huntingtin. This approach now is being tested for clinical efficacy in HD in a Phase III clinical trial.
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Hormonal Contraception and HIV: Does DMPA Increase Risk of Transmission?
This special feature includes a review of the evidence for the effect of hormonal and nonhormonal methods on HIV risk.
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Identify and Treat Urologic Injuries at Hysterectomy to Reduce Fistulas
In a large population-based cohort study, genitourinary fistulas were increased significantly if ureteral and/or bladder injuries were not identified and treated at the time of hysterectomy.
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Patients' Views on Adverse Events Following Pelvic Reconstructive Surgery
Patients see poor functional outcomes as severe adverse events following pelvic floor surgery.
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Should Obesity Be a Contraindication to Postpartum Tubal Sterilization?
In this retrospective cohort study of 279 women undergoing postpartum partial salpingectomy after vaginal delivery, the mean operative time for women with a BMI ≥ 30 kg/m2 was only 5.5 minutes longer than the time for women with a BMI < 30 kg/m2.
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Is There Group Beating?
How should one proceed in analyzing this challenging rhythm strip?
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Dupilumab Injection (Dupixent)
This is the first FDA-approved treatment for chronic rhinosinusitis with nasal polyposis.
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Mechanism of Persistence of Moraxella catarrhalis in Patients With COPD
Investigators examined the mechanism that allows Moraxella catarrhalis to persist in some patients with COPD.
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Early vs. Delayed Cardioversion: A Nonshocking Result
For patients presenting to an ED with recent-onset atrial fibrillation, using rate control and outpatient cardioversion only as needed was associated with a high rate of spontaneous conversion within 48 hours of arrhythmia onset and noninferior short-term outcomes compared to immediate cardioversion in the ED.