Clinical
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Airplane-Triggered Headaches
Severe, unilateral headaches that occur during airplane travel, particularly during landing, are most likely a variant of migraine headaches triggered by changes in cabin pressure.
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When to Administer the 13-Valent Pneumococcal Conjugate Vaccine: A Review of the ACIP Recommendations
Recently revised guidelines no longer recommend the 13-valent pneumococcal conjugate vaccine for most healthy adults.
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Seven Days of Antibiotics Was Noninferior to 14 Days for Gram-Negative Rod Bacteremia
In patients with gram-negative rod bacteremia, patients receiving seven days of antibiotics had similar 90-day mortality, readmission rates, and rates of recurrent bacteremia as patients receiving 14 days of antibiotic.
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Balanced Crystalloids Reduce Mortality in Critically Ill Adults With Sepsis or Septic Shock
Compared to saline, balanced crystalloids reduced in-hospital mortality and major adverse kidney events within 30 days in critically ill patients with sepsis or septic shock.
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The Epidemic of Vaping-Associated Lung Injury
Since June 2019, there has been a considerable rise in reported cases of vaping-associated lung injury.
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Infectious Disease Alert Updates
Objects of Delusional Infestation; Urine Eosinophils Unreliable; Tecovirimat for Laboratory-Acquired Vaccinia
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Omeprazole Magnesium, Amoxicillin, and Rifabutin Delayed-Release Capsules (Talicia)
The FDA has approved a fixed-dose combination, rifabutin-based (RFB) regimen to treat Helicobacter pylori infection.
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Markers and Mechanisms of Chronic Fatigue Following Mononucleosis
Chronic disabling fatigue affects up to 2% of adolescents and often follows Epstein-Barr virus-related mononucleosis. No clinically significant infectious, immune, neuroendocrine, or autonomic biomarker or pathophysiologic mechanism has been identified to differentiate those with mononucleosis who go on to develop chronic fatigue from those who recover.
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Cefazolin and Ertapenem as Salvage Therapy in Methicillin-Susceptible Staphylococcus aureus Bacteremia
Cefazolin (CZ) and ertapenem combination therapy was successfully used to salvage 11 cases of persistent methicillin-susceptible Staphylococcus aureus bacteremia. Modest in vitro synergy between CZ and ertapenem was demonstrated on testing of six clinical isolates, but in vivo activity appeared more potent in an animal model than as predicted by in vitro activity.
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Fulminant Clostridioides difficile Infection: Hold the IV Metronidazole?
The combination of oral vancomycin and intravenous metronidazole is not superior to vancomycin alone in the treatment of fulminant infection due to Clostridioides difficile.