Clinical
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Treating Ebola Virus Infection
Two monoclonal antibody preparations have been demonstrated to significantly reduce mortality in patients with Ebola virus infection.
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Preventing Ebola Virus Infection
In a scientific/public health triumph, the first vaccine for the prevention of Ebola virus infection has been approved. If administered prior to 10 days after exposure, its protective efficacy is 100%.
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Ebola in Democratic Republic of the Congo: Confronting Potential Disaster
The second largest outbreak of Ebola virus infection has come under control.
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Efficacy of Vitamin C Infusion on Outcomes in Sepsis-Induced ARDS
In this randomized, double-blinded, placebo-controlled trial, intravenous vitamin C infusion did not influence a change in the modified Sequential Organ Failure Assessment score from the time of infusion to four days compared to placebo.
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Longer Antibiotic Courses for Pneumonia Do Not Improve Outcomes, But Cause More Adverse Effects
Two-thirds of general medicine patients with pneumonia received excess antibiotic therapy, with 93.2% of the unnecessary duration occurring after hospital discharge. Excess antibiotic therapy did not improve mortality or morbidity outcomes, although each additional antibiotic day was associated with 3% increased odds of antibiotic-associated adverse drug events.
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Antimicrobial Stewardship in Critical Care
Antimicrobial stewardship is the responsibility of everyone involved in the care of critically ill and hospitalized patients. This review discusses some of the key principles and practices of successful antimicrobial stewardship programs, particularly as they relate to critical care.
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Optimal Antithrombic Therapy After PCI for Atrial Fibrillation Patients
In three subgroups of coronary artery disease patients with atrial fibrillation, apixaban plus a P2Y12 inhibitor provided superior safety and similar efficacy outcomes as treatment with warfarin, aspirin, or both for six months.
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The Risk of Endocarditis With Bacteremia
Interrogation of the Danish National Patient Registry revealed bacteremia due to Enterococcus faecalis was most likely to be associated with infective endocarditis; thus, echocardiography is warranted in these patients.
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Aggressive Afterload Reduction Does Not Improve Outcomes in Acute Decompensated Heart Failure
The authors of the GALACTIC trial found no benefit from an aggressive vasodilation approach for patients hospitalized with acute decompensated heart failure.
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Subclinical Atrial Fibrillation Detected By Implanted Loop Recorders: Common, But How Burdensome?
In older patients with risk factors for stroke drawn from the general population, previously undiagnosed and asymptomatic episodes of atrial fibrillation are detected frequently via implantable loop recorder monitoring, allowing for early initiation of anticoagulation therapy.