Clinical
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Is Cannabis Abuse During Pregnancy Associated with Poor Neonatal Outcomes?
Cannabis use disorder is associated with small but significant increased risks measured in multiple neonatal outcomes.
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Permanent Contraception Regret in the Modern Age
In this Canadian cross-sectional survey of a convenience sample of 844 patients who had undergone female sterilization, the prevalence of regret was 16%.
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Pelvic Exams During Annual Gynecologic Visits
A retrospective chart review of 1,121 patients undergoing annual gynecology exams showed that 1.2% (95% confidence interval [CI], 0.5 to 1.9) of asymptomatic patients had physical exam findings on pelvic exam compared to 32.4% (95% CI, 27.0 to 37.8) of symptomatic patients.
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Bigeminy and What Else?
The medical providers in this case were concerned the cause of the bigeminal rhythm in the figure below was sinoatrial block. Do you agree? Are there other things to be concerned about?
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Bempedoic Acid (Nexletol) and Bempedoic Acid and Ezetimibe (Nexlizet)
The U.S. Food and Drug Administration is expected to update the indications for bempedoic acid and bempedoic acid/ezetimibe. Esperion has submitted clinical evidence in the form of Cholesterol Lowering via Bempedoic Acid an ACL-inhibiting Regimen (CLEAR) that demonstrated that bempedoic acid was associated with a lower risk of major adverse cardiovascular events compared to placebo. Bempedoic acid and bempedoic acid/ezetimibe are distributed by Esperion as Nexletol and Nexlizet, respectively.
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Is Screening First-Degree Relatives of Cardiomyopathy Patients Worthwhile?
An observational study of screening first-degree relatives of patients with dilated cardiomyopathy revealed 14% will show either dilated left ventricles, low left ventricular function, or both. These findings are more common if the relatives have been diagnosed with hypertension or are obese, but their frequency is not altered by sex or race.
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Long-Term Antiplatelet Therapy After PCI
The five-year follow-up of patients randomized to clopidogrel vs. aspirin monotherapy beyond one year after percutaneous coronary intervention has shown that clopidogrel is noninferior, but not superior, to aspirin for preventing the combined endpoint of adverse cardiovascular or major bleeding events.
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Dyeing to Death: Examining the Risks of Red 40 and High-Fat Diets
This study exploring colorectal cancer development reveals that Allura Red AC (Red 40), a synthetic dye prevalent in many American diets, causes significant deoxyribonucleic acid damage and colonic inflammation in mice, especially when combined with a high-fat diet.
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Vitamin D and Marine n-3 Fatty Acids Reduce Autoimmune Diseases
Continued use of vitamin D3 and n-3 fatty acids reduced the incidence of autoimmune diseases such as psoriasis.
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Acute Small Fiber Neuropathy
Acute-onset small fiber neuropathy most often is precipitated by infections, medication side effects, or vaccinations. Most cases recover spontaneously.