Clinical
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The Risk of Endocarditis With Bacteremia
Interrogation of the Danish National Patient Registry revealed bacteremia due to Enterococcus faecalis was most likely to be associated with infective endocarditis; thus, echocardiography is warranted in these patients.
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Fever of Unknown Origin Due to Cat Scratch Disease
Disseminated cat scratch disease may present as a fever of unknown origin.
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Longer Antibiotic Courses for Pneumonia Do Not Improve Outcomes, Do Cause More Adverse Effects
Excess antibiotic therapy did not improve mortality or morbidity outcomes, although each additional antibiotic day was associated with 3% increased odds of antibiotic-associated adverse drug events.
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Laryngeal Injury Is Common After 12 Hours of Intubation
After 12 hours of intubation, most patients showed laryngeal injury, including mucosal ulceration, that led to impaired breathing and voicing 10 weeks after extubation.
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Management of Nontraumatic Intracranial Emergencies: A Clinical Update
This article attempts to provide evidence-based, practical guidelines to the frontline clinician in the nontrauma intensive care setting.
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Efficacy of Class I vs. Class III Antiarrhythmic Drugs in Obese Patients
In an observational cohort of patients with atrial fibrillation, obese patients were less likely than nonobese patients to avoid symptomatic recurrence on sodium channel blocking agents in contrast to a roughly equivalent response in both groups to potassium channel blocking agents.
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Heart Failure-Exacerbating Medications
In a large, diverse cohort of Medicare patients hospitalized for heart failure exacerbations, almost half were on medications known to exacerbate heart failure; more than one-third were on these agents at discharge.
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Home Oral Factor Xa Inhibitor Treatment for Pulmonary Embolism
Low-risk pulmonary embolus patients discharged in < 48 hours on rivaroxaban recorded a nominal three-month rate of recurrent emboli or major bleeding, suggesting such patients do not need to be hospitalized for treatment of pulmonary emboli.
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Rivaroxaban After Transcatheter Aortic Valve Replacement
In this randomized trial of post-transcatheter aortic valve replacement patients without a separate indication for anticoagulation, a rivaroxaban-based approach was associated with a higher risk of death and thromboembolic complications compared with dual antiplatelet therapy.
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Heart Rate and Diastolic Blood Pressure in Chronic Aortic Regurgitation Patients
A retrospective observational study of patients with moderate to severe aortic regurgitation showed the independent predictive value of diastolic blood pressure and resting heart rate for all-cause mortality under medical management.