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COVID-19 and Children
In China, children of all ages have been infected with SARS-CoV-2 and seem to follow a relatively mild clinical course.
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COVID-19: What Providers Should Know
The disease associated with COVID-19 is now a significant event in world history, with uncertain but likely major consequences for individuals, families, healthcare workers, health systems, and the global economy. There remains a great deal to learn.
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Implications of COVID-19 for Primary Care
Primary care physicians often are the first to communicate with potential COVID-19 patients. Without definitive testing, it is challenging to reliably provide an accurate differential diagnosis, but there is a developing list of signs and symptoms associated with COVID-19.
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Antibiotic Therapy to Reduce the Incidence of Ventilator-Associated Pneumonia After Cardiac Arrest
In this prospective, randomized trial, intravenous amoxicillin-clavulanate (dosed three times daily and given for two days) administered to patients admitted with out-of-hospital cardiac arrest due to a shockable rhythm reduced the incidence of early ventilator-associated pneumonia.
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Maximal Lung Recruitment Strategy Does Not Reduce Ventilator-Free Days in the Setting of Acute Respiratory Distress Syndrome
In this randomized trial, daily maximal recruitment trials failed to reduce ventilator-free days in the setting of acute respiratory distress syndrome, but increased the risk of cardiovascular adverse effects.
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Impact of Intensive Care Unit Personnel Decisions and Staffing on Patient Outcomes
Nurses with relatively high autonomy, alongside a dedicated intensive care unit (ICU) clinical pharmacist and 24/7 intensivist coverage, were associated with the lowest hospital mortality, shortest ICU lengths of stay, and shortest mechanical ventilator durations compared to other staffing models.
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Vitamin C, Thiamine, and Hydrocortisone for Septic Shock
The combination of vitamin C, thiamine, and hydrocortisone did not improve outcomes compared with hydrocortisone alone in patients with septic shock.
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Many Serious Cardiac Complications of Pregnancy Are Preventable
Investigators determined about half of serious cardiac complications of pregnancy are preventable.
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Coronary CT Angiography to Identify Plaque Stabilization
Researchers identified subjects with no known coronary artery disease drawn from a large international, multicenter registry of coronary CT angiography. Subjects were divided into matched pairs with and without a subsequent acute coronary syndrome event. The authors demonstrated those with a high density of calcium plaques experienced the fewest events, suggesting high-density calcium plaques are stable.
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TAVR in Bicuspid Aortic Valves
Investigators assessed the Society of Thoracic Surgeons/American College of Cardiology transcatheter aortic valve replacement (TAVR) data, with a focus on the use of newer TAVR devices in patients with bicuspid aortic valve vs. tricuspid aortic valves. They found the outcomes post-procedure and for one year are not significantly different between the two types of native valve anatomy.