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Immunomodulatory Treatment of Disseminated Coccidioidomycosis
A previously healthy 4-year-old boy with no prior serious illnesses was diagnosed with disseminated coccidioidomycosis with prominent skin and bone involvement. Despite treatment with liposomal amphotericin B, antifungal azoles, and surgical debridement, the patient developed progressive disease. Treatment with interferon-gamma slowed disease progression, and later treatment with interleukin-4 and interleukin-13 blockade induced remission of his infection.
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Rotavirus Vaccine Is Safe and Effective
Routine rotavirus vaccination of infants, when implemented broadly, is safe and is associated with reductions in diarrhea-related hospitalizations, mortality, and morbidity (such as malnutrition) in children.
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Outcomes with Daptomycin Plus a β-Lactam Compared to Daptomycin Alone for MRSA Bacteremia
In a retrospective cohort study, investigators found the addition of a β-lactam antibiotic to daptomycin led to less clinical failure (60-day all-cause mortality and/or 60-day recurrence) in patients with methicillin-resistant Staphylococcus aureus bacteremia.
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COVID-19 in Early Infancy
An evaluation of 18 infants with COVID-19 in the first three months of their lives found that the illness generally was not severe despite the presence of very high viral loads.
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COVID-19: Lessons from Spring Break
A high rate of COVID-19 occurred as the result of an outbreak in spring breakers. Rapid recognition and intervention, as well as the youth and good health of those infected, was effective in limiting the adverse consequences.
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DASH Is Revisited and Updated, Lowering Subclinical Cardiac Injury Markers
In individuals without pre-existing cardiovascular disease, the Dietary Approaches to Stop Hypertension diet plan and a diet consisting of fruits and vegetables, given over eight weeks, lowered biomarkers for cardiac strain and injury.
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The Relationship Among Step Count, Step Intensity, and Mortality in Adults
The authors of this observational study of 4,840 adults show an association between higher number of steps taken daily and lower all-cause mortality, lower mortality from cardiovascular disease, and lower mortality from cancer, but no association between intensity of steps and mortality in any of those areas.
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Updated Guidelines for HPV Vaccine
Recommendations call for providing vaccine to boys and girls starting at age 9 years.
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COVID-19 and Steroids: Is There a Consensus on the Controversy?
A retrospective, single-center cohort study among 201 adults admitted with COVID-19 pneumonia revealed that risk factors associated with the development of acute respiratory distress syndrome (ARDS) and progression from ARDS to death included older age, neutrophilia, organ dysfunction, and coagulation derangement. Treatment with methylprednisolone may be beneficial for these patients.
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First-Pass Success Rate Between Rocuronium and Succinylcholine in Emergent Out-of-Hospital Endotracheal Intubation
This randomized, single-blind, noninferiority trial compared rocuronium and succinylcholine for rapid sequence intubation. Rocuronium was noninferior to succinylcholine with respect to the primary endpoint of first-pass intubation success.