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Cilostazol Appears Effective for Long-Term Secondary Stroke Prevention
More trials in Western countries should be initiated to assess the effects of cilostazol treatment on cognitive decline and functional outcomes, as well as on the progression of small vessel disease in the brain. Studies from Asia suggest it is a promising treatment, but it has not been studied sufficiently in clinical trials.
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2020 Updated LTBI Treatment Guidelines
A committee recommended three rifamycin-based regimens and two alternate six- or nine-month isoniazid monotherapy regimens for latent tuberculosis infection treatment. They gave priority to shorter-course regimens with similar efficacy, higher rates of completion, and favorable tolerability compared with the former standard nine-month regimen of isoniazid.
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Diet Modification in Older Women with Fecal Incontinence
This study highlights the need for everyone to inquire and start conversations about fecal incontinence symptoms with patients and empowers clinicians to discuss simple lifestyle modifications that may be of great benefit.
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Confusion, Skepticism Abound Regarding Convalescent Plasma as a COVID-19 Therapeutic
From collection to analysis to reporting, it seems everyone registered a complaint about the entire process.
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Guideline: Clinicians Should Use NSAIDs for Acute Musculoskeletal Pain
Orgs call for topical treatment as first-line agent for acute pain from non-low back-related injuries that lasts no more than four weeks.
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Nerve Disorders from Mutations in the BSCL2 Gene
The neuromuscular syndromes caused by BSCL2 gene mutations may mimic several other disorders, including Charcot-Marie-Tooth disease and amyotrophic lateral sclerosis.
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Molecular and Cellular Correlates of Human Nerve Regeneration
Specific and objective measures of improvement after carpal tunnel decompression (i.e., electrodiagnostic testing, somatosensory function, and intraepidermal nerve fiber density) also correlated with upregulation of ADCYAP1/PACAP genes. These genes may be potential therapeutic targets in the future.
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Dermatomyositis Sine Dermatitis Is an Important Clinical Entity
Dermatomyositis is an autoimmune disorder of skeletal muscle associated with a variety of auto-antibodies and specific muscle pathology but it may not have a skin rash. Muscle pathology and antibody determinations are important for accurate diagnosis and treatment.
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Randomized Diagnostic Trial of First-Line Genome Sequencing in Pediatric White Matter Disorders
The results of this study indicate that first-line genome sequencing in pediatric patients with suspected genetic white matter disease is more diagnostically efficient, defined as higher diagnostic efficacy and shorter time to diagnosis, than current standard of care approaches.
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Plasma Phospho-Tau217 Is a Promising Alzheimer’s Disease Biomarker
Validation and replication of findings in the use of the blood biomarker phospho-tau 217 for the diagnosis of Alzheimer’s disease holds out the possibility for a new era in the early diagnosis and treatment of this debilitating illness.