Clinical
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‘Hygiene Theater’
In a study of surfaces contaminated by an actual patient, no viable virus could be found. Similar studies of common community coronavirus found the virus survived less than one to three hours after drying on various surfaces, including surgical gloves and aluminum. People’s fears have been exaggerated by bad science and worse public policy.
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DASH Is Revisited and Updated, Lowering Subclinical Cardiac Injury Markers
In individuals without pre-existing cardiovascular disease, the Dietary Approaches to Stop Hypertension diet plan and a diet consisting of fruits and vegetables, given over eight weeks, lowered biomarkers for cardiac strain and injury.
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Repeat Infections with Endemic Coronaviruses and Possible Implications for COVID-19
Repeat infection with endemic seasonal coronavirus occurs commonly and raises concerns about immunity to SARS-CoV-2 as well as about the efficacy of vaccines in the protection against infection because of this virus.
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The COVID-19 Pandemic: What Comes Next? Lessons from Seasonal Coronaviruses
In temperate regions other than China, human seasonal coronaviruses circulate most heavily during the winter months, overlapping with influenza and respiratory syncytial virus. This may be the eventual pattern for SARS-CoV-2.
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Application of Acetic Acid to Identify Lesions During Colposcopy
In this prospective study, one minute of acetic acid application was found to be sufficient to identify the most severe colposcopic lesion in 96.7% of subjects.
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Outcomes in Pregnant Women Treated with Anti-Tumor Necrosis Factor-Alpha Biologic Therapy
In this population-based cohort study of 1,027 infants born to women treated with anti-TNF-α biologic therapy, there was an increased prevalence of preterm birth (adjusted odds ratio [aOR], 1.61; 95% confidence interval [CI], 1.29-2.02), cesarean delivery (aOR, 1.57; 95% CI, 1.35-1.82), and small for gestational age neonates (aOR, 1.36; 95% CI, 0.96-1.92) when treatment with anti-TNF was compared to non-biologic systemic treatment. Since disease processes varied greatly in these pregnant women, it was difficult to rule out confounding by disease severity (confounding by indication).
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Tamoxifen for the Management of Bleeding Irregularities in Contraceptive Implant Users
In this double-blind, randomized controlled trial, etonogestrel implant users with prolonged or frequent menses who took 10 mg of tamoxifen twice daily for seven days as needed for irregular bleeding had an average of 9.8 (95% confidence interval, 4.6-15.0) more consecutive days of amenorrhea over a 90-day period compared to those who took a placebo.
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Race Correction in Clinical Calculations — Is It Time to Reconsider?
Many clinical calculators use race as a predictive variable to assess risk for outcomes. Although most of the tools assume a genetic disposition for these outcomes, other factors, such as health disparities and other potential confounders, are more likely to be the underlying reasons for any race-related differences in outcomes.
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Food-Insecure Infants at Higher Risk for Obesity
Poor nutrition and overfeeding are possible reasons for the association.
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Plasma Biomarker May Indicate When Athletes Can Return to Play After Concussion
A better understanding of these biomarkers may help improve health and safety of athletes.