Clinical
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Can Antioxidant Intake Prevent Coronary Artery Disease?
A study of single nucleotide polymorphisms (SNP) that increase blood levels of diet-derived antioxidants in three large individual subject genetic databases did not demonstrate a relationship between SNPs and coronary artery disease.
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Are Beta-Blockers Still Relevant After a Myocardial Infarction?
A large, contemporary, nationwide, observational study of post-myocardial infarction beta-blocker administration shows that after three months, there were no beneficial effects on adverse cardiovascular events to continued beta-blocker use.
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Statins and Muscle Symptoms: Cause and Effect?
An analysis of three large simvastatin trials revealed muscle symptoms on simvastatin are common, but true myopathy is rare and can be predicted by evaluating certain risk factors for its development, which can help guide patient management.
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Is Effective Transcatheter Tricuspid Repair Becoming a Reality?
In two trials of transcatheter devices treating tricuspid regurgitation, the authors observed high efficacy and low adverse event rates.
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Oral Progestogens for Prevention of Miscarriage
In this double-blind, randomized clinical trial, 406 pregnant women were randomized to dydrogesterone or placebo. There were no statistically significant differences in the primary outcome (miscarriage before 20 weeks of gestation; relative risk, 0.897; 95% confidence interval, 0.548-1.467; P = 0.772), which occurred in 12.8% and 14.3% in the dydrogesterone and placebo arms, respectively. The use of dydrogesterone in women with threatened miscarriage for the prevention of early pregnancy loss in the first trimester failed to decrease the miscarriage rate or increase the live birth rate.
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Is HPV Testing Superior to Pap Testing Alone in Women at Risk of Cervical Cancer?
In this registry-based screening study of women in Catalonia, Spain, a negative human papillomavirus (HPV) and cytology co-test at baseline was associated with a cumulative incidence of cervical precancer of 0.4% at five years and 1.3% at nine years, compared to 27% among women with abnormal HPV testing at baseline.
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Pregnancy After Treatment for Pelvic Floor Disorders
This consensus document was developed as a reference for physicians caring for and advising women in pregnancy following prior surgical treatment for pelvic floor disorders.
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The Pregnancy Perspective: What Has COVID-19 Affected?
In this cross-sectional descriptive study, women using the Ovia pregnancy app expressed receiving adequately safe maternal care during the COVID-19 pandemic, but voiced concerns related to obtaining infant supplies and prenatal education.
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New Guidelines Reinforce Need for Change in Cervical Cancer Screening Practice
Screening standards for cervical cancer have changed over the past two decades, including several updates since the first consensus guidelines, published in 2001 by the American Society of Colposcopy and Cervical Pathology. The 2020 revision is based on data showing that patients’ risk of developing cervical precancer or cancer can be estimated using screening test results, biopsy results, and consideration of personal patient factors.
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Educational Sessions for Women with Opioid Use Disorder Improve Engagement
A Maine family planning clinic launched a program to reach women who experience barriers to reproductive healthcare, counseling, and testing for sexually transmitted infections. The program focused on outreach, sending an educator to various locations and providing an educational session for women who are especially vulnerable, including those who use opioids.