Clinical
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Cognitive Benefit of Rivastigmine in Parkinson’s Disease Dementia with Orthostatic Hypotension
Individuals with Parkinson’s disease dementia and orthostatic hypotension (OH) showed more robust cognitive improvement from rivastigmine vs. those without OH. The anti-OH effect of rivastigmine probably mediates this better response.
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How to Record Reliable Blood Pressure Measurements
A small, community-based study to detect hypertension revealed one week of twice-daily home blood pressure (BP) measurements are more reliable and more accurately predict increased left ventricular mass than clinic or 24-hour ambulatory BP monitoring.
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Prior Metformin Use in Patients with Diabetes Hospitalized for COVID-19
Investigators found metformin use before COVID-19 hospitalization for patients with diabetes was associated with a lower risk of death.
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New Risk Factors for Atherosclerosis
An analysis of the Women’s Health Study based on a recent questionnaire about adverse pregnancy outcomes showed hypertensive disorders of pregnancy and low birth weight are independent predictors of subsequent atherosclerotic cardiovascular disease.
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Can Antioxidant Intake Prevent Coronary Artery Disease?
A study of single nucleotide polymorphisms (SNP) that increase blood levels of diet-derived antioxidants in three large individual subject genetic databases did not demonstrate a relationship between SNPs and coronary artery disease.
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Are Beta-Blockers Still Relevant After a Myocardial Infarction?
A large, contemporary, nationwide, observational study of post-myocardial infarction beta-blocker administration shows that after three months, there were no beneficial effects on adverse cardiovascular events to continued beta-blocker use.
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Statins and Muscle Symptoms: Cause and Effect?
An analysis of three large simvastatin trials revealed muscle symptoms on simvastatin are common, but true myopathy is rare and can be predicted by evaluating certain risk factors for its development, which can help guide patient management.
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Is Effective Transcatheter Tricuspid Repair Becoming a Reality?
In two trials of transcatheter devices treating tricuspid regurgitation, the authors observed high efficacy and low adverse event rates.
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Oral Progestogens for Prevention of Miscarriage
In this double-blind, randomized clinical trial, 406 pregnant women were randomized to dydrogesterone or placebo. There were no statistically significant differences in the primary outcome (miscarriage before 20 weeks of gestation; relative risk, 0.897; 95% confidence interval, 0.548-1.467; P = 0.772), which occurred in 12.8% and 14.3% in the dydrogesterone and placebo arms, respectively. The use of dydrogesterone in women with threatened miscarriage for the prevention of early pregnancy loss in the first trimester failed to decrease the miscarriage rate or increase the live birth rate.
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Is HPV Testing Superior to Pap Testing Alone in Women at Risk of Cervical Cancer?
In this registry-based screening study of women in Catalonia, Spain, a negative human papillomavirus (HPV) and cytology co-test at baseline was associated with a cumulative incidence of cervical precancer of 0.4% at five years and 1.3% at nine years, compared to 27% among women with abnormal HPV testing at baseline.