Clinical
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Acute Myocardial Infarction, or Related to COVID-19?
The ECG in the figure was obtained from a man in his 30s. How would one interpret this tracing if told the patient’s only symptom was recent shortness of breath on exertion that he had not experienced?
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Vericiguat Tablets (Verquvo)
Vericiguat is indicated to lower the risk of cardiovascular death and heart failure hospitalization in adults with symptomatic chronic heart failure and an ejection fraction less than 45%.
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Is There an Ideal Time to Administer Antihypertension Medications?
Taking all antihypertensive agents before bed vs. upon awakening in hypertensive patients showed there was less hypertension during sleep and few cardiovascular events over a six-year follow-up.
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Time-Restricted Eating, Weight Loss, and Metabolism
A randomized clinical trial comparing time-restricted eating with a 16-hour fasting interval to a structured three-meal-per-day control group resulted in equivalent weight loss in both groups and no reduction in metabolic markers in either group.
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Healthy or Not: The Controversy Over Egg Consumption Continues
A large meta-analysis showed higher consumption of eggs (eating more than one egg daily) was not associated with an increased risk of cardiovascular disease, and was associated with a lower risk of coronary artery disease.
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Stem Cell Transplantation for MS Treatment
In this small study of the effect of mesenchymal stem cell treatment, both intravenous and intrathecal, in patients with progressive multiple sclerosis, the treatment was shown to be safe, and there was a trend showing some benefit in slowing disease progression, compared to the sham group. A larger randomized controlled trial is needed to confirm these early findings.
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Spontaneous Intracranial Hypotension Syndrome
A systematic review of spontaneous intracranial hypotension demonstrates heterogeneity in clinical and radiographic presentations. Diagnostic studies, such as brain imaging and lumbar puncture, may be unrevealing, and the clinician may have to rely on symptom patterns alone to make a diagnosis.
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Efficacy and Safety of Cannabidiol in Treatment of Focal Seizures Associated with Tuberous Sclerosis Complex
Cannabidiol used as an add-on therapy for intractable focal seizures in patients with tuberous sclerosis complex was efficacious. Cannabidiol also had an acceptable adverse event profile, but frequently induced transient elevation of liver enzymes.
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Gluten/Celiac Disease Neuropathy
Gluten neuropathy should be suspected in any patient who presents with a neuropathy and has a history of gastrointestinal disease. The diagnosis is made using blood serology plus intestinal mucosal biopsy.
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Long-Term Treatment of Hereditary Amyloid Neuropathy with Patisiran
Hereditary transthyretin-mediated amyloidosis with polyneuropathy is effectively treated by patisiran, a lipid nanoparticle ribonucleic acid interference that binds to transthyretin (TTR) messenger RNA and inhibits TTR production in the liver, resulting in reduction of the serum TTR concentration. Treatment effect has been sustained during a five-year open-label extension study.