Clinical
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Does Maternal BMI Influence the Success of Trial of Labor After Cesarean?
In this retrospective cohort study between May 2007 and April 2016, women undergoing a trial of labor after cesarean (TOLAC) were analyzed to determine if pre-pregnancy or delivery obesity status made an impact on TOLAC success. Overall, maternal body mass index did not have a significant effect on TOLAC success rates.
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Tranexamic Acid for the Prevention of Obstetric Hemorrhage
In this prospective, cohort, pharmacokinetic-pharmacodynamic (PKPD) dose-finding study by Ahmadzia and colleagues, 30 pregnant women (10 women in each study arm) received 5 mg/kg, 10 mg/kg, or 15 mg/kg doses of tranexamic acid for the prevention of postpartum hemorrhage. Advanced PKPD modeling demonstrated that 600 mg of tranexamic acid was the optimal dose to use in the prevention of postpartum hemorrhage.
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Drospirenone and Estetrol Tablets (Nextstellis)
Nextstellis can be prescribed to women of reproductive potential to prevent pregnancy.
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Vitamin D and COVID-19
Low levels of vitamin D are associated with in-hospital mortality in patients with COVID-19, but causality is unknown.
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Dairy, Bone Health, and Menopause
An analysis of data from the Study of Women’s Health Across the Nation cohort did not reveal a significant association between daily dairy intake frequency, femoral and spine bone mineral density loss, and non-traumatic fracture risk among women transitioning to menopause.
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Giving the Cold Shoulder to Drug Therapy for Atrial Fibrillation
In two randomized trials published simultaneously, cryoballoon ablation proved superior to drug therapy for prevention of arrhythmia recurrence in patients with paroxysmal atrial fibrillation.
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U.S. Supports Waiving Intellectual Property Protections for COVID-19 Vaccines
The aim is to accelerate the spread of shots around the globe.
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Is a History of Palpitations Useful for Detecting Atrial Fibrillation?
An analysis of the utility of implanted loop recorders to detect subclinical atrial fibrillation in high-risk individuals showed that among common arrhythmia-compatible symptoms, only palpitation was predictive of discovering episodes of atrial fibrillation.
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Can Mitral Regurgitation Prevent Atrial Thrombosis Caused by Atrial Fibrillation?
A study of nonrheumatic patients with atrial fibrillation who were inadequately or not anticoagulated undergoing transesophageal echocardiography before cardioversion showed moderate-to-severe mitral valve regurgitation attenuates the risk of finding left atrial thrombi or spontaneous echo contrast and could be considered a thromboembolic risk modifier.
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Using His Bundle Pacing for Cardiac Resynchronization: Does It Hold Up to the Standard?
In a randomized trial of patients with heart failure and left bundle branch block, cardiac resynchronization therapy via permanent His bundle pacing produced similar short-term outcomes to traditional biventricular pacing, albeit with higher pacing thresholds.