Clinical
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A Prospective Look at the Course of Untreated ADHD in Pregnancy Gains Attention
Twenty-five women with perinatal attention-deficit hyperactivity disorder were followed prospectively during pregnancy for changes in anxiety, depression, perceived stress, and functional impairment. Statistically significant differences in mood and functional impairment in the family domain were found in those who discontinued their psychostimulant.
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FDA, CDC Sign Off on Third COVID-19 Vaccine
Johnson & Johnson’s COVID-19 vaccine is the first single-shot solution to receive an agency emergency use authorization.
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Acute Myocardial Infarction, or Related to COVID-19?
The ECG in the figure was obtained from a man in his 30s. How would one interpret this tracing if told the patient’s only symptom was recent shortness of breath on exertion that he had not experienced?
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Vericiguat Tablets (Verquvo)
Vericiguat is indicated to lower the risk of cardiovascular death and heart failure hospitalization in adults with symptomatic chronic heart failure and an ejection fraction less than 45%.
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Is There an Ideal Time to Administer Antihypertension Medications?
Taking all antihypertensive agents before bed vs. upon awakening in hypertensive patients showed there was less hypertension during sleep and few cardiovascular events over a six-year follow-up.
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Time-Restricted Eating, Weight Loss, and Metabolism
A randomized clinical trial comparing time-restricted eating with a 16-hour fasting interval to a structured three-meal-per-day control group resulted in equivalent weight loss in both groups and no reduction in metabolic markers in either group.
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Healthy or Not: The Controversy Over Egg Consumption Continues
A large meta-analysis showed higher consumption of eggs (eating more than one egg daily) was not associated with an increased risk of cardiovascular disease, and was associated with a lower risk of coronary artery disease.
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Stem Cell Transplantation for MS Treatment
In this small study of the effect of mesenchymal stem cell treatment, both intravenous and intrathecal, in patients with progressive multiple sclerosis, the treatment was shown to be safe, and there was a trend showing some benefit in slowing disease progression, compared to the sham group. A larger randomized controlled trial is needed to confirm these early findings.
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Spontaneous Intracranial Hypotension Syndrome
A systematic review of spontaneous intracranial hypotension demonstrates heterogeneity in clinical and radiographic presentations. Diagnostic studies, such as brain imaging and lumbar puncture, may be unrevealing, and the clinician may have to rely on symptom patterns alone to make a diagnosis.
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Efficacy and Safety of Cannabidiol in Treatment of Focal Seizures Associated with Tuberous Sclerosis Complex
Cannabidiol used as an add-on therapy for intractable focal seizures in patients with tuberous sclerosis complex was efficacious. Cannabidiol also had an acceptable adverse event profile, but frequently induced transient elevation of liver enzymes.