Clinical
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Aducanumab-avwa Injection (Aduhelm)
The FDA has approved a new, but controversial, treatment for Alzheimer’s disease. -
Using Procalcitonin to Limit Antibiotic Treatment for Sepsis Reduces Infection-Related Adverse Events
By shortening the duration of antibiotic therapy, a procalcitonin-guided protocol decreased the rate of infection-associated adverse effects, decreased costs, and reduced mortality in patients with sepsis. -
Air Filters and Asthma
Children with asthma showed improved small airway mechanics following indoor filtration of particulates (2.5 µm and greater) using high-efficiency particulate air filtration devices. -
The Effect of Antiviral Drugs on COVID-19 Outcomes and Mortality
The WHO Solidarity Trial Consortium found remdesivir, hydroxychloroquine, lopinavir, and interferon regimens produced “little or no effect” on relevant outcomes. -
Treating Anxiety Disorders in Primary Care
Anxiety disorders are the most prevalent mental health problem worldwide. Collectively, these disorders are at the core of 20% of primary care visits in the United States. This article reviews in-depth several common disorders of anxiety — GAD, PD, and SAnD — with a focus on diagnosis and treatment relevant to the primary care provider.
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U.S. Slips in Blood Pressure Management
After years of improvement in this area, investigators recently observed troubling decline in rate control. -
Infectious Disease Alert Updates
Sexual Distancing vs. Access to Care During COVID; Zoonosis in Federal Service Dogs; Echinococcus in Saskatchewan -
Q fever — A ‘Gift’ that Keeps on Giving
Chronic Q fever is a frequent and potentially lethal complication of acute infection that may first be diagnosed a decade afterward. -
Antibiotic Treatment of Prosthetic Joint Infections: How Long Is Long Enough?
A six-week course of antibiotic therapy was “not noninferior” to a 12-week course in patients with prosthetic joint infection, at least in those who had undergone debridement and implant retention.
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Rapid Stool Tests for Gastrointestinal Pathogens in Children Who Vomit
For children with acute vomiting (but not diarrhea), rapid rectal swab testing for bacterial and viral pathogens has potential for helping clinicians confirm a diagnosis of gastroenteritis and, thus, avoid unnecessary evaluation for other diagnoses.