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MRI Changes and Functional Outcomes Among Adults with Severe HSV Encephalitis
Herpes simplex virus is a common cause of encephalitis worldwide. When treated promptly, the mortality rate decreases from 70% to 15%, but many patients remain disabled. This multicenter cohort study analyzed magnetic resonance imaging in patients diagnosed with herpes simplex encephalitis admitted to the intensive care unit to identify factors associated with poor outcome at 90 days.
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Infectious Disease Alert Updates
California mandates COVID-19 vaccine for healthcare workers; Seasonal coronavirus in stem cell transplant
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Adherence to the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Does Not Lead to Improved Clinical Outcomes
A longitudinal study from a single healthcare system found that adherence to the Medicare Severe Sepsis and Septic Shock Early Management Bundle resulted in some changes in process measures, but did not lead to improvements in clinical outcomes.
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Treatment of Presumed Urinary Tract Infection in Afebrile Males: How Long Is Long Enough?
Symptom resolution after seven days of antibiotic therapy in afebrile males with presumed urinary tract infection was not inferior to 14 days of therapy.
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COVID-19: Effective Post-Exposure Prophylaxis
Subcutaneous administration of a combination of anti-SARS-COV-2 antibodies effectively prevented COVID-19 in most household contacts of cases.
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Updated Sexually Transmitted Infection Guidelines
The Centers for Disease Control and Prevention has updated their recommendations for the treatment of several sexually transmitted infections, including gonorrhea, trichomoniasis, bacterial vaginosis, pelvic inflammatory disease, and those due to Chlamydia trachomatis and Mycoplasma genitalium.
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Neutrophil Extracellular Traps and COVID-19
Neutrophil extracellular traps (NETs) contribute to immune-mediated inflammation and thrombosis. Donor neutrophils were stimulated with plasma from patients hospitalized with COVID-19. R406 (metabolically active component of fostamatinib) abrogated release of NETs in vitro.
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Children Hospitalized with SARS-CoV-2
Two recently published studies give a clear, consistent finding: About three-fourths of children hospitalized with SARS-CoV-2 do not have severe COVID-19-related illness but are merely identified as infected when subjected to screening tests. Surveys reporting the number or incidence of SARS-CoV-2-infected hospitalized children likely overestimate the actual burden of disease.
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Women Remain Underrepresented in Cardiology Research
Ageism, lack of diverse leadership among several reasons a prominent committee listed as barriers.
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Emotional Eating and Obesity
This review of research regarding the link between emotional eating (eating in response to unpleasant emotions) and obesity in adults suggested several factors that contribute to emotional eating and methods for patients to reduce it.