Clinical
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A Null Finding: Vitamin D3 Supplementation Not Associated with Depression Prevention
This randomized clinical trial involving more than 18,000 nondepressed adults at baseline and followed for five years concludes that supplementation with vitamin D3 (vs. placebo) is not associated with a decrease in symptoms of depression. -
Determining the ‘Culprit’ Artery
How would one interpret the ECG in the figure, obtained in the ED from a middle-aged man with new chest pain? -
Aducanumab-avwa Injection (Aduhelm)
The FDA has approved a new, but controversial, treatment for Alzheimer’s disease. -
Using Procalcitonin to Limit Antibiotic Treatment for Sepsis Reduces Infection-Related Adverse Events
By shortening the duration of antibiotic therapy, a procalcitonin-guided protocol decreased the rate of infection-associated adverse effects, decreased costs, and reduced mortality in patients with sepsis. -
Air Filters and Asthma
Children with asthma showed improved small airway mechanics following indoor filtration of particulates (2.5 µm and greater) using high-efficiency particulate air filtration devices. -
The Effect of Antiviral Drugs on COVID-19 Outcomes and Mortality
The WHO Solidarity Trial Consortium found remdesivir, hydroxychloroquine, lopinavir, and interferon regimens produced “little or no effect” on relevant outcomes. -
Treating Anxiety Disorders in Primary Care
Anxiety disorders are the most prevalent mental health problem worldwide. Collectively, these disorders are at the core of 20% of primary care visits in the United States. This article reviews in-depth several common disorders of anxiety — GAD, PD, and SAnD — with a focus on diagnosis and treatment relevant to the primary care provider.
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U.S. Slips in Blood Pressure Management
After years of improvement in this area, investigators recently observed troubling decline in rate control. -
Infectious Disease Alert Updates
Sexual Distancing vs. Access to Care During COVID; Zoonosis in Federal Service Dogs; Echinococcus in Saskatchewan -
Q fever — A ‘Gift’ that Keeps on Giving
Chronic Q fever is a frequent and potentially lethal complication of acute infection that may first be diagnosed a decade afterward.