Clinical
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Cost to Treat U.S. Patients with Rare Diseases Likely Underestimated
NIH, FDA, other groups form consortium to speed gene therapy development.
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Antibiotics for Appendicitis, Revisited
One year later, researchers present updated data that strengthen the alternative to surgery approach.
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Regulators Sign Off on COVID-19 Vaccine ‘Mix and Match’
Federal agencies expand, clarify guidance on booster shots.
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What Is the ‘Bix Rule?’
The ECG in the figure was obtained from a middle-aged man with a history of exertional chest pain and dyspnea. How would one interpret this tracing? Does the red arrow in lead II show a sinus P wave?
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Atogepant Tablets (Qulipta)
Atogepant can be prescribed to prevent episodic migraine in adults.
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Progression of Coronary Calcium on Statin Treatment
In those treated with statins vs. those who were not, statins decreased plaque volume in plaques with little or no calcium (plaque regression) and increased calcium density without changes in plaque volume in calcified plaques (plaque stabilization).
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Adjuvanted Zoster Vaccine: Persistent Protection
The adjuvanted recombinant zoster vaccine efficacy is high and persistent, with apparent plateauing at > 84% four to six years after vaccination.
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First-Line Therapy for Hypertension
When comparing angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARBs) to treat hypertension, researchers observed no difference in major cardiovascular events — but a better safety profile for ARBs.
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Carbohydrates and Insulin Resistance: Pondering Food Quality vs. Quantity
Researchers posit that solving the obesity epidemic is not as simple as eating less and moving more.
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Electrodiagnostic Findings in Thoracic Outlet Syndrome
The diagnosis of thoracic outlet syndrome may be difficult and relies on specific clinical, imaging, vascular, and electrodiagnostic features. None of the currently recommended treatments have been shown to be effective, but there are few randomized clinical treatment trials.