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Merck announced on September 30th that it is voluntarily withdrawing rofecoxib (Vioxx) from the worldwide market.
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Oseltamivir treatment of children with influenza A virus infection was associated with the selection of resistant mutants in 18%.
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The ECG in the Figure was interpreted as showing sinus tachycardia with non-specific ST-T wave abnormalities. Do you agree?
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Overall, caspofungin was at least as effective as liposomal amphotericin B for empiric therapy in persistently febrile neutropenic patients. Caspofungin therapy was associated with greater survival 7 days after the end of therapy, greater efficacy in treatment of baseline fungal infections, and it was better tolerated.
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An outbreak of conjunctivitis caused by a macrolide resistant unencapsulated pneumococcus occurred among naval trainees who were receiving azithromycin as prophylaxis against atypical pneumonia.
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Exposure of E. coli to ampicillin results in selection of a preexisting population of persister cells. Persistence may also be induced by ampicillin exposure via activation of the SOS response.
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Longer-Term Symptoms of WNV Fever; Hepatitis E Hits Iraq; Maggot You Another Appetizer?; SARS and the Environment.
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Erythromycin and the Risk of Sudden Death; Vaccine Shortage Putting Americans At Risk; FDA Actions.
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Kiso and colleagues in Japan collected serial upper respiratory tract samples from children receiving oseltamivir for treatment of influenza A (H3N2), for isolation of the virus. Mutations in neuraminidase were identified in virus obtained from from 9 of 50 (18%) immunocompetent children treated with oseltamivir. Eight of the 9 contained mutations previously identified as conferring resistance to oseltamivir, while the ninth had a novel mutation.