Clinical
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Earlier Coronary Artery Bypass Grafting After Ticagrelor Discontinuation Is Safe
In a trial that included acute coronary syndrome patients treated with ticagrelor, undergoing coronary bypass surgery within two to three days was noninferior to the guideline-recommended five to seven days regarding severe bleeding.
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Pharmacotherapy for Atrial Fibrillation with Anticoagulation-Associated Intracranial Hemorrhage
A study of apixaban vs. no anticoagulation in patients following an anticoagulant for atrial fibrillation-related intracerebral hemorrhage exhibited a high risk of stroke and vascular death, regardless of whether the patients were treated subsequently with apixaban.
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Role of Beta-Blockers in Heart Failure with Preserved Ejection Fraction
Discontinuation of beta-blockers in heart failure with preserved ejection fraction patients significantly improved quality of life scores and expanded exercise capacity.
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Tailoring Dietary Recommendations to Protect Cognitive Health
Preventing inflammation as patients age is becoming key focus of lowering dementia risk.
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WHO: Corticosteroids OK for Children with Multisystem Inflammatory Syndrome
International group updates guidelines for treating young patients with this rare-but-serious COVID-19-related complication.
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Is This Wellens’ Syndrome?
The ECG in the figure is from a young adult man known to have a bicuspid aortic valve. He presented to the ED following a presyncopal episode. The patient has not experienced chest pain recently. Does this patient have Wellens’ syndrome?
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Eculizumab for Refractory Myasthenia Gravis
Eculizumab, a monoclonal antibody that inhibits the C-5 complement terminal complex formation, is a safe and effective treatment for generalized myasthenia gravis with acetylcholine receptor auto-antibodies, even after failed treatment with other immunosuppressive regimens.
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Varenicline Nasal Spray (Tyrvaya)
Varenicline nasal spray is indicated to treat the signs and symptoms of dry eye disease.
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Intensive Blood Pressure Lowering Does Not Affect Small Vessel Disease Progression
Intensive blood pressure lowering was not associated with worsening but did not demonstrate any benefit in this population over standard blood pressure management.
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Infections Before Age 20 Years Increase the Risk of Multiple Sclerosis
The relationship between childhood infections and the risk of multiple sclerosis is supported by increasing evidence. Using the Swedish Total Population Register, researchers found that patients diagnosed with infection in adolescence showed an increased risk of multiple sclerosis, even after exclusion of infectious mononucleosis, pneumonia, and central nervous system infection.