Clinical
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Single IRB Concerns Include IT Limitations, Process Variations
Consistency, standardization, speed and efficiency, and simplification are reported benefits. Challenges include timeliness of the research review process, insufficient communication, and uncertainty at local institutions.
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Researchers Can Remove Recruitment Barriers in Alzheimer’s Trials
What can be consolidated, made simpler, or translated? What data can be collected outside your research setting? How can you communicate better with prospective and current research participants?
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Screening Tests to Determine Study Eligibility Are Not Foolproof
IRBs and researchers should expand eligibility criteria to diversify representation, remove extraneous inclusion/exclusion criteria, and eliminate some screening tests if they are not strictly necessary, particularly tests that produce many false-negative or false-positive results.
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New Data on IRB Members’ Perceptions of Violations
Failure to properly store data and neglecting to maintain project records are the two most common IRB violations, according to a recent survey of 242 faculty members at research-intensive universities in the United States.
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Informed Consent Challenges with High-Risk Surgery
There appears to be room for improvement when it comes to surgeons talking with patients about shared decision-making and providing specifics about quality of life after procedures.
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Patients Can Request Ethics Consults, But Almost None Do
In a recently published paper, the authors reported if patients are empowered to ask for ethics consults, it can mean more patient-centered care, better shared decision-making, and a stronger patient/physician relationship.
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Excluding People with Serious Mental Illness from Research Is Ethical Problem
With current treatment methods, many individuals with serious mental illness function well, maintain employment, hold valued roles in their communities, and can consent to and participate in research.
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Accessing Hormonal Contraception by Pharmacy Prescriptions
Access to effective contraception is critical for avoiding unintended pregnancy, which accounts for about 45% of pregnancies overall in the United States. A stopgap step to increasing access is to expand prescribing authority to pharmacists.
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Benefits of Delayed Umbilical Cord Clamping
Delayed umbilical cord clamping at the time of delivery resulted in higher mean hematocrit concentrations, with no significant maternal or neonatal complications when compared to immediate umbilical cord clamping.
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Intravenous Iron: Does This Therapy Increase the Risk of Infection?
In this systematic review and meta-analysis, among all populations, intravenous iron was associated with a slight increased risk of infection (relative risk, 1.17; 95% confidence interval, 1.04-1.31) compared to oral iron or no iron. However, there was no difference in mortality or length of hospital stay.