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  • A Pathogen to Consider More Broadly in Patients with Pneumonia: Legionella

    The incidence of legionellosis in the United States increased significantly in 2003-2005 compared to previous years. This was due mostly to an upsurge of cases in the northeastern and southern United States and a shift of disease from elderly to middle-aged adults. Legionellosis should be considered as a potential cause of pneumonia in a broad range of patients, rather than a small subset with specific risk factors.
  • IV Thrombolysis 3-4.5 Hours after Stroke: Time for a Change?

    Intravenous thrombolysis is safe and effective for the treatment of ischemic stroke in the time window of 3-4.5 hours after the onset of symptoms.
  • Management of Type B Aortic Dissection

    Uncomplicated type B aortic dissection (origin distal to left subclavian artery) is usually treated medically. However, early mortality is 10%-12%, and is due to complications.
  • Non-invasive Ventilation in Acute Cardiogenic Pulmonary Edema

    In patients with acute cardiogenic pulmonary edema, CPAP or NIV produces a more rapid improvement in respiratory distress and arterial blood gases than standard therapy.
  • Clinical Briefs in Primary Care Supplement

  • Pharmacology Watch

    5-α reductase inhibitors and hip fracture in men; the effects of drug-reimbursement policy on outcomes; new guidelines for type 2 diabetes; beta-blocker-associated brady-cardia is linked to CVD events; FDA Updates.
  • Soft-Tissue Rheumatism: Diagnosis and Management

    Soft-tissue rheumatism often is a challenging disorder for the primary care physicians. The patient's symptoms often are vague, and the physical examination and laboratory testing often do not give comforting confirmatory findings. This issue reviews common conditions that afflict many of our patients and that, although often not serious, cause significant distress and morbidity. With the proper history and attention to presenting features, effective and professionally rewarding treatments are available.
  • ECG Review: A Fast Heart with Chest Pain

    The patient whose 12-lead ECG and rhythm strip is shown above had chest discomfort at the time this tracing was recorded. In light of this history, how do you interpret the tracing?
  • Vitamin D Levels and the Risk of Mortality in the General Population

    Correlating the findings in the 13,331 adults 20 years or older in the Third National Health and Nutrition Examination Survey (NHANES III) revealed that vitamin D deficiency is a risk factor for developing cardiovascular disease and is associated with increased all-cause mortality.
  • Pharmacology Watch

    Ongoing safety review of tiotropium; raloxifene reduces the risk of endometrial cancer; one-day treatment with famciclovir may be as effective as 3-day treatment with valacyclovir; new Clinical Practice Guideline from the American College of Physicians regarding pharmacologic treatment for low bone density and osteoporosis; FDA Actions.