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Indications for surgical or interventional management in acute type B aortic dissection (ABAD) include malperfusion syndromes, progression of dissection, and aneurysm expansion.
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There is no medical therapy for aortic stenosis (AS), and balloon aortic valvuloplasty (BAV) has sub-optimal long-term results. The incidence of AS increases with age and, thus, many patients have significant comorbidities.
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The safety and diagnostic performance of right and left ventricular endomyocardial biopsy in patients with suspected myocarditis or non-ischemic cardiomyopathy is poorly understood, especially with contemporary techniques, such as MRI guidance.
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The incretin class of medications (exenatide, liraglutide, sitagliptin, saxagliptin) all share the favorable quality of not being associated with weight gain.
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A recombinant, polyethylene glycol (PEG) mammalian urate oxidase (uricase) has been approved by the FDA for treatment of hyperuricemia. Uricase metabolizes urate to allantoin, a water-soluble metabolite, which is cleared renally. Pegliticase is marketed by Savient Pharmaceuticals as Krystexxa™.
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A systematic review shows that the three classical symptoms of paroxysmal cough, post-tussive emesis, and inspiratory whoop are helpful for the diagnosis, but cannot be relied upon to rule in or rule out pertussis as the cause of a chronic cough.
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Initiating treatment for hypercholesterolemia at age 30 years instead of age 60 years might very well prevent not just 30% of the CAD events as occurred in the 5-year statin trials, but perhaps as many as 60% of the CAD events lifetime.
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In a very large Norwegian study, use of screening mammography was associated with a reduction in the rate of death from breast cancer, but the screening itself accounted for only about a third of the total reduction in death rate.
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FDA Advisory Committee recommends approval of dabigatran, safety of proton pump inhibitors, effectiveness of glucosamine and chondroitin, FDA Actions.