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Current guidelines for NSAID use in patients at high risk for ulcer disease recommend use of NSAIDs selective for cyclo-oxygenase-2 inhibition or nonselective NSAIDs plus a proton pump inhibitor. This study compared diclofenac plus omeprazole with celecoxib in patients with previous GI hemorrhage. Neither regimen successfully prevented rebleeding, and both exhibited significant toxicities.
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Screening for lung cancer with helical CT has high costs and uncertain benefits.
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Ice Cream-Evoked Headaches Study: A Randomized Trial of Accelerated vs Cautious Ice Cream Eating Regimen; Treatment of Antidepressant-Associated Sexual Dysfunction with Sildenafil; Prophylactic Treatment of Migraine with an Angiotensin II Receptor Blocker
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The FDA has approved cyclosporine ophthalmic emulsion for the treatment of dry eyes due to keratoconjuctivitis sicca (KCS) and associated reduced tear production. Cyclosporine is an immunomodulating agent that increases tear production in patients with KCS.
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Pravastatin given for 3 years reduced the risk of coronary disease in elderly individuals. The PROSPER study therefore extends to elderly individuals the treatment strategy currently used in middle aged people.
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Retrospective review of needle emg findings on 45 patients studied during a 20-year period, with surgically verified compression of a single lumbosacral nerve root, was undertaken to determine the accuracy of traditional myotomal charts used to localize nerve root involvement.
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Among patients with plasma cell dyscrasias and polyneuropathy, most have monoclonal gammopathy of undetermined significance (MGUS), of which 50% are IgM in type. Most of these demonstrate activity against myelin-associated glycoprotein (MAG).
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Disorders of memory are frequently studied, but exceptional recall abilities have been the subject of relatively few investigations. In an effort to understand the neural basis of superior recall,
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The Centers for Disease Control and Prevention published Smallpox Vaccination and Adverse ReactionsGuidance for Clinicians in the Jan. 24th edition of Morbidity and Mortality Weekly Report. The guidance is a thorough review of the smallpox vaccine with a well-illustrated compendium of complications.
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Synopsis: Postpartum fever after cesarean delivery is associated with an increased risk of uterine rupture during a subsequent trial of labor.
