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Vigabatrin (VGB) is an antiepileptic drug (AED) whose putative mechanism of action is to increase inhibitory tone in the brain by blocking the metabolism of gamma-amino butyric acid (GABA) by irreversibly binding to GABA transaminase.
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Benign hyperckemia may be defined as serum elevation of creatine kinase (CK) in an asymptomatic patient or in a patient with nonspecific symptoms, including muscle pain, fatigue, cramps, stiffness, normal neurological examination, and normal or nondiagnostic electrodiagnostic (nerve conduction studies and electromyography) studies.
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Taylor and associates report a case of Hashimoto encephalopathy in an adolescent girl with a 9-month history of what was initially diagnosed as chronic fatigue syndrome.
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Cardiac resynchronization reduces the mortality of progressive heart failure in patients with symptomatic left ventricular dysfunction and dyssynchrony.
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In this study, a European consortium of investigators evaluated the ability of an automatic external cardioverter defibrillator (AECD) to detect and treat arrhythmias in the in-hospital setting.
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Low intensity warfarin therapy effectively prevents recurrent venous thromboembolism, according to a recent study in the New England Journal of Medicine.
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In patients with active lymphocytic myocarditis and persistent heart failure for greater than 6 months, those with circulating cardiac autoantibodies and no viral genomes detected on myocardial biopsy are the most likely to benefit from immunosuppressive therapy.
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While the clinical benefit of oral N-acetylcysteine on reducing rates of contrast nephropathy for a given patient is unproven, it should be considered for all patients with abnormal renal function referred for elective coronary angiography.
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Although fibrinolytic therapy was highly successful for thrombosis of prosthetic mechanical heart valves, a high complication rate limits its use to nonsurgical candidates.