Clinical
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Ethical Controversy Persists Over Organ Procurement Method
Ethical debate continues over a controversial method of procuring organs for transplantation: Normothermic regional perfusion with controlled donation after circulatory determination of death.
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IRBs May Need to Seek Outside Expertise; More Data Are Needed
It is impossible for any IRB to claim an exhaustive range of methodological and disciplinary expertise within their membership. Without the right expertise, the quality of IRB review comes into question. But for a variety of reasons, IRBs may not be taking advantage of the option to use outside experts.
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Efforts to Improve Ethics Education for Nurses
Nurses probably have heard of the ethical principles of autonomy, beneficence, nonmaleficence, and justice. However, these principles might not be discussed in terms of how they apply to nursing practice and patient care.
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Greater Awareness of Reporting Bias on Antidepressants, Yet Problem Persists
An investigator who was part of a landmark study on the efficacy of antidepressants recently revisited reporting transparency in this area of research.
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Ethical Concerns Persist Over Reporting Bias in Clinical Trials
Several changes could be made, including enforcement of penalties for delays in reporting trial results; journals prioritizing accuracy between published results and the original study protocols; and mitigating the problem of selective registration, publication, and reporting on ClinicalTrials.gov.
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Regarding Exercise Capacity Past Age 75 Years, What Is Normal?
A group of researchers delivered results that could help inform clinicians about the expected exercise test performance of older patients.
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Detecting Cancer Treatment-Related Cardiac Dysfunction
When searching for breast cancer-related cardiac dysfunction, a sequential algorithm using echo ejection fraction and strain parameters produced an area under the receiver operating curve of 89%. Adding biomarkers did not improve the ability to diagnose cardiac dysfunction.
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Comparing CT Angiography to Invasive Angiography for Stable Chest Pain Patients
A trial of initial coronary CT angiography vs. invasive angiography revealed outcomes over a median 3.5-year follow-up were similar, but procedure-related complications were more common in the invasive group.
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Thrombolysis vs. Surgery for Thrombosed Mechanical Prosthetic Valves
A study of patients with obstructive prosthetic valve thrombosis that deployed low-dose, slow infusion thrombolysis or surgery using shared decision-making, showed thrombolysis was highly effective and resulted in fewer major complications than surgery.
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Comparison of Treatments Highlights Poor Outcomes for TAVR Patients with Infective Endocarditis
In this analysis of a large registry of transcatheter aortic valve replacement patients with confirmed endocarditis, most were treated with antibiotics without surgery. In-hospital and one-year mortality rates were high and were not much better in patients who underwent surgery.