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Selumetinib, a selective MEK1/2 inhibitor, achieved objective responses in 15% of patients with recurrent low-grade serous ovarian cancer (LGSOC). The data are relevant as this uncommon tumor type is associated with general chemoresistance, frequent aberration in the MAPK pathway, and prolonged overall survival compared with its more common high-grade variant. Phase 3 trials are planned.
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A review of incident cases of venous thrombosis in women using oral contraceptives (OCs) in a U.S. insurance database found that use of drospirenone-containing OCs containing 20 ìg of ethinyl estradiol (EE) was associated with a two-fold increase in risk compared to levonorgestrel pills. This risk was not increased with use of 30 ìg EE drospirenone pills.
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Low levels of anti-Müllerian hormone in combination with an elevated day 2-3 follicle-stimulating hormone is associated with a high rate of aneuploid embryos.
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Childhood chronic inflammatory demyelinating polyradiuculoneuropathy follows a similar course as the adult counterpart and responds well to treatment with intravenous immunoglobulin.
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The authors performed a two-part analysis of the contraceptive choice Project, a prospective cohort study in which women in the St. Louis, Missouri, region received a reversible contraceptive method of their choice for up to 3 years at no cost.
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Cholesterol-reducing statin agents have been associated preclinically with cancer cell growth inhibition and metastases prevention.
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Conventional wisdom in obstetrics implies that woen with previous uterine surgery outside the lower uterine segment — whether myomectomy or classical cesarean section — incrue an unacceptable risk for uterine rupture during pregnancy.
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1998 was a landmark year for men’s sexuality. the FDA approved sildenafil (Viagra®), a medication that now has household name familiarity.