Clinical
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Sweating for Sleep: Examining Evening Exercise and its Effects on Sleep Duration
This small, randomized crossover trial demonstrates that short, repetitive bouts of early evening exercise lead to an increase in total sleep time compared to prolonged sitting.
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Multicomponent Breastfeeding Interventions in Women with a Body Mass Index > 25
The study found no statistically significant differences in breastfeeding outcomes between the intervention and control groups at various postpartum time points, although the intervention group received more hospital-based support, while the control group sought more private lactation support.
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What Do Patients Know About Anti-Müllerian Hormone Testing?
In this randomized, controlled, online questionnaire trial, participants who received evidence-based information about anti-Müllerian hormone (AMH) testing had lower interest in getting an AMH test (mean difference, 1.05; 95% confidence interval, 0.83-1.30) than individuals who viewed the control information from a direct-to-consumer website.
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Rethinking Endometrial Thickness Thresholds that Prompt Endometrial Biopsy to Rule Out Endometrial Cancer
In a retrospective review of 1,494 pre- and postmenopausal Black individuals who underwent transvaginal ultrasonography, 24 of 210 individuals (11.4%) with endometrial cancer had an endometrial thickness lower than the threshold for undergoing biopsy to detect cancer.
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Reproductive Healthcare in Adolescents with Autism and Other Developmental Disabilities
This cohort study of 3,723 female adolescents from the Kaiser Permanente healthcare system in California found that adolescents with autism or developmental disability were less likely to see an OB/GYN or be prescribed contraception compared with their typically developing peers. This study identified disparities present in reproductive healthcare for this population, despite higher rates of menstrual-related diagnoses.
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Metabolic Dysfunction-Associated Steatotic Liver Disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic metabolic disease that you may never have heard of. MASLD, formerly known as non-alcoholic fatty liver disease (NAFLD), is the most prevalent liver disease worldwide. MASLD affects 30% of the world’s population, more than half of those people with obesity, and more than 70% of people with type 2 diabetes. While many clinicians may see patients with slightly elevated transaminases and assume it is fatty liver, MASLD is not benign and often begins well before laboratory changes. This article reviews the pathogenesis, diagnosis, and natural history of MASLD; known treatments; and future therapies.
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Sofpironium Topical Gel (Sofdra)
The U.S. Food and Drug Administration has approved a second topical anticholinergic product for the treatment of hyperhidrosis.
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Enlargement of Choroid Plexus in Subacute COVID-19 Patients
The choroid plexus is a network of capillaries whose main role involves facilitating cerebrospinal fluid production and the exchange of nutrients and waste products between the central nervous system and the bloodstream. Immune cells are present near the choroid plexus. Enlargement of the choroid plexus has been noted in patients with multiple sclerosis.
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Chlorthalidone vs. Hydrochlorothiazide for Hypertension
A subgroup analysis of those with prior myocardial infarction or ischemic stroke in the Diuretic Comparison Project for the treatment of hypertension has found that this higher-risk group experiences fewer major adverse cardiovascular events while taking chlorthalidone compared to hydrochlorothiazide, but at the expense of more hypokalemia.
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TB Screening Dismayingly Low in Those at Risk
Screening for latent tuberculosis (TB) infection in persons at risk is woefully lax in our country — and yet, reactivation TB is such an eminently preventable disease.