Clinical Publication
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IRBs Strive to Improve Consistency of Study Protocol Decisions
Is a study protocol OK to go forward? Or are many changes needed for recruitment, consent, or other processes? IRB decisions often are inconsistent on these points — even at the same institution, and sometimes at the same IRB.
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Preventing Age Disparities in Cancer Trials
A leading researcher explains why patients should have equity regarding their ability to access clinical trials, to the greatest extent reasonably possible, in this Q&A.
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Analyses: Older Patients Excluded from Many Research Studies
Investigators learned age disparities were worse for industry-funded trials; for trials with enrollment criteria restrictions based on age cutoffs or performance status; for trials that evaluated a targeted, systemic therapy; and for lung cancer trials.
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Lack of Basic Knowledge on Clinical Trials Makes Study Recruitment Harder
Survey respondents with a history of cancer and those who have heard of ClinicalTrials.gov knew more about trials. Such knowledge also was more abundant among college graduates and those who had been asked to participate in a trial.
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Bebtelovimab Injection
The FDA has issued an emergency use authorization for a monoclonal antibody that demonstrated efficacy against the omicron variant of COVID-19.
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VIRSTA vs. PREDICT: Which Is Best for Anticipating Endocarditis?
Researchers in Columbia put predictive scoring methods through their paces.
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Importance of Exercise Testing-Associated Ventricular Ectopy
A study of asymptomatic subjects without known cardiovascular disease undergoing treadmill exercise testing and followed for a mean of 20 years showed high-grade premature ventricular contractions during exercise recovery (but not during exercise) are predictive of subsequent cardiovascular mortality.
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Herpes Simplex Virus 2 Meningitis in Adults
The incidence of herpes simplex virus 2 meningitis in adults in Denmark over a six-year period was 0.7/100,000 population per year, with 91% of cases occurring in the absence of immunocompromise.
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CABG Wins Again for Multivessel Disease
Fractional flow reserve-guided percutaneous coronary intervention failed to meet noninferiority guidelines vs. coronary artery bypass grafting.
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Coronary Calcium Score Zero: Are You Home Free?
Among those with a coronary calcium score of 0 after a median follow-up of 16 years, current cigarette smoking, diabetes, and hypertension were independently associated with the development of atherosclerotic cardiovascular disease.