Clinical Publication
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Women at Higher Risk for Intracranial Aneurysm Ruptures
Women with ruptured aneurysms were older than men, were less often smokers, and more often experienced internal carotid artery aneurysms. They also tended to produce larger-sized aneurysms than men.
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Men More Likely to Produce High-Risk, Dangerous Carotid Artery Plaques
Investigators found significant differences in mean total plaque volume between men and women. Men were more likely to experience intraplaque hemorrhage and produce lipid-rich necrotic cores with coexistence of calcifications. Men also were more likely to exhibit thin or ruptured fibrous caps or ulcerations in their atherosclerotic plaques.
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Weight Loss and Other Interventions to Alleviate Obstructive Sleep Apnea
Obesity is a primary cause of obstructive sleep apnea (OSA), and improvements in weight and other lifestyle factors can yield benefits for OSA and related comorbidities.
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Extend Life Expectancy by Achieving Type 2 Diabetes Therapeutic Goals
Investigators analyzed gains in life expectancy by achieving treatment goals, finding significant gains from lower body mass index, glycated hemoglobin, systolic blood pressure, and low-density lipoprotein cholesterol.
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Updated Aspirin Guidance from the U.S. Preventive Services Task Force
The authors of new recommendations advise avoiding initiating aspirin for primary prevention of cardiovascular disease in adults age 60 years or older, individualizing decisions based on characteristics and preferences for patients.
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Is the Canadian Syncope Risk Score Valid?
Researchers found the Canadian Syncope Risk Score accurately predicts which patients are low risk for discharge. However, since it is largely driven by the physician’s final risk classification at ED discharge, the score’s clinical utility is uncertain.
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Anticoagulation Therapy in Octogenarians with Atrial Fibrillation
In patients age 80 years and older with atrial fibrillation who were not considered for oral anticoagulants because of serious comorbidities, one-quarter of the recommended daily dose of edoxaban was superior to placebo for preventing thromboembolic events.
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Outcomes of COVID-19-Associated Acute Myocarditis
In a review of COVID-19-associated acute myocarditis, investigators learned it is a rare complication that can occur without concomitant pneumonia, and frequently presents as cardiogenic shock. With supportive therapy, the short-term mortality rate is low.
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Sodium Restriction in Chronic, Stable Heart Failure Patients
A study of a low-sodium diet for chronic, stable heart failure patients after one year showed no difference in hard clinical outcomes, but the degree of sodium restriction was modest.
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Oral Anticoagulation Falls Short as Default Treatment Post-TAVR
In patients without an indication for anticoagulation undergoing transcatheter aortic valve replacement, treatment with edoxaban did not significantly affect the incidence of leaflet thrombosis as detected by CT scans.