Clinical Publication
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Comparing CT Angiography to Invasive Angiography for Stable Chest Pain Patients
A trial of initial coronary CT angiography vs. invasive angiography revealed outcomes over a median 3.5-year follow-up were similar, but procedure-related complications were more common in the invasive group.
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Thrombolysis vs. Surgery for Thrombosed Mechanical Prosthetic Valves
A study of patients with obstructive prosthetic valve thrombosis that deployed low-dose, slow infusion thrombolysis or surgery using shared decision-making, showed thrombolysis was highly effective and resulted in fewer major complications than surgery.
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Comparison of Treatments Highlights Poor Outcomes for TAVR Patients with Infective Endocarditis
In this analysis of a large registry of transcatheter aortic valve replacement patients with confirmed endocarditis, most were treated with antibiotics without surgery. In-hospital and one-year mortality rates were high and were not much better in patients who underwent surgery.
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Donepezil Transdermal Patch (Adlarity)
Donepezil transdermal system can be prescribed to treat mild, moderate, and severe dementia of the Alzheimer’s type.
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Bloodstream Infections During COVID-19
Severity of illness, prolonged hospital stays, use of mechanical ventilation, and use of immune-modulating agents in patients with COVID-19 may have contributed to observed increases in hospital-acquired blood stream infections and attendant mortality.
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Empower Patients With Education Resources About Pelvic Floor Disorders
Online patient resources for pelvic floor disorders on the American Urogynecologic Society patient portal are underused by women with pelvic floor disorders.
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The Effects of Diet, Nutrition, and Weight on Fibromyalgia
A review of evidence for the use of dietary interventions in the treatment of fibromyalgia shows symptom reduction associated with a variety of healthy diets. Weight loss may be key to understanding this connection, but more research is needed.
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How Fast Can You Recognize This Rhythm?
How might the reader interpret the two-lead rhythm strip shown in the figure? Is there AV block? If so, is this complete (i.e., third-degree) AV block?
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Daridorexant Tablets (Quviviq)
Daridorexant can be prescribed to adult patients with insomnia characterized by difficulty with sleep onset and/or sleep maintenance.
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Delaying Antibiotics in Patients with Suspected Infection Increases Risk of Septic Shock
A retrospective cohort study revealed delaying the first dose of antibiotics in patients suspected of presenting with an infection in the ED led to a higher risk of progressing to septic shock and in-hospital mortality. Every hour antibiotics were delayed raised the risk of septic shock by 4%.