Clinical Publication
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Effectiveness of Dietary Supplements on Lipid and Inflammatory Biomarkers
In a comparison of rosuvastatin 5 mg/day, six common dietary supplements marketed for improving heart health, and placebo, none reduced high-sensitivity C-reactive protein levels. Only rosuvastatin significantly reduced LDL cholesterol levels compared to placebo.
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Long-Term Maintenance Therapy After Percutaneous Coronary Intervention
An extended six-year follow-up of the HOST-EXAM study revealed the consistent benefit of the primary endpoint of fewer major cardiovascular events and less bleeding with clopidogrel vs. low-dose aspirin monotherapy in post-percutaneous coronary intervention patients who were on dual antiplatelet therapy for one year.
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How to Diagnose ATTR Cardiac Amyloidosis
A retrospective study of patients with confirmed cardiac amyloidosis showed negative light chain biomarkers and a typical pattern of cardiac amyloid on cardiac MRI was highly specific for the diagnosis of the transthyretin subtype and may obviate the need for further testing before starting treatment.
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ECMO-Supported CPR Disappoints for Treating Out-of-Hospital Cardiac Arrest
For patients with out-of-hospital cardiac arrest that was refractory to initial resuscitation efforts, adding extracorporeal membrane oxygenation to standard CPR did not result in a significant improvement in survival with favorable neurologic outcome.
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Surgical Risk of Mitral Valve Repair, Updated
A contemporary update of the Society of Thoracic Surgeons risk calculator for operative mortality and morbidity in nonemergent primary mitral valve repair for regurgitation shows an operative mortality rate of 1.2%, with a conversion to replacement of 6%, in more than 53,000 patients.
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Considering Periodontal Disease as a Risk Factor of Cardiovascular Disease
Researchers used data from the 2013 to 2014 period of the National Health and Nutrition Examination Survey to study possible connections between poor oral health and the likelihood of developing cardiovascular disease.
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Considerations of Measuring Salt Intake
Those who rarely or never added salt to their food and strongly adhered to the Dietary Approaches to Stop Hypertension diet exhibited the lowest incidence of subsequent cardiovascular disease.
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Poor Cardiovascular Health a Predictor for Premature Brain Aging
Worse cardiovascular health at age 36 years can predict worse brain aging and associated cognitive problems later in life.
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The Efficacy of Prenatal Patients Using a Mindfulness App
This randomized trial conducted early in the pandemic with women from an obstetric and gynecologic practice found use of a mobile app promoting mindfulness practice (such as meditation) was associated with a decrease in perceived stress, self-reported anxiety and depression, and sleep disturbance in the intervention group.
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Tocilizumab Injection (Actemra)
The FDA has approved tocilizumab injection to treat COVID-19 among hospitalized adult patients who are receiving systemic corticosteroids and require supplemental oxygen.