Clinical Publication
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Moderate-Intensity Exercise OK for Statin Users with Muscle Pain
The go-to drug therapy patients use to lower their bad cholesterol levels can cause muscle pain for some, but researchers found moderate exercise would not exacerbate that pain.
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Double BBB, or Complete AV Block?
The ECG in the figure is from a woman who complained she had been experiencing chest pain for several days. What is the rhythm? Is there complete AV block?
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Zavegepant Nasal Spray (Zavzpret)
Zavegepant can be prescribed to treat migraine, with or without aura, in adults.
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Multivitamin-Mineral Supplementation vs. Cocoa Extract for Cognition
Researchers followed participants for three years and determined daily cocoa supplement use was not associated with cognitive enhancement in older adults, whereas a multivitamin supplement was associated with significant cognitive benefits.
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Insulin Resistance at the Blood-Brain Barrier in Alzheimer’s Disease
Alterations in cerebrovascular insulin receptor isoform levels were associated with Alzheimer’s disease pathology and caused deficits in insulin signaling at the level of the blood-brain barrier.
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Prosocial vs. Self-Rewarding Behavior and Their Effects on Stress Recovery
Two randomized, controlled studies were created to examine the effects of giving gifts vs. receiving gifts after stressful situations. They both revealed the “giving” group reported recovering from stress faster, showing more happiness, showing less desire, and reporting no significant difference in relaxation compared to the “receiving” group and a control group.
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The Connection Between Bereavement, Sleep, and Inflammation
This study of the association of sleep disturbance with more markers of inflammation in widows and widowers compared to controls revealed self-reported sleep disturbances are more strongly correlated with increased markers of inflammation in bereaved individuals.
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Sparsentan Tablets (Filspari)
Sparsentan can be prescribed to alleviate proteinuria in adults with primary immunoglobulin A nephropathy who are at risk of rapid disease progression — generally, a urine protein-to-creatinine ratio 1.5 mg/g or higher.
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Long-Term Maintenance Therapy After Percutaneous Coronary Intervention
An extended six-year follow-up of the HOST-EXAM study revealed the consistent benefit of the primary endpoint of fewer major cardiovascular events and less bleeding with clopidogrel vs. low-dose aspirin monotherapy in post-percutaneous coronary intervention patients who were on dual antiplatelet therapy for one year.
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Does COVID Vaccination Prevent Car Crashes?
In a large study, lack of COVID vaccination was associated with more incidents of car crash injuries.